Raubaite Radvile, Galinauskaite Sarlota, Rasteniene Ruta, Zaleckas Linas
Institute of Odontology, Faculty of Medicine, Vilnius University, Vilnius, LTU.
Cureus. 2025 May 5;17(5):e83497. doi: 10.7759/cureus.83497. eCollection 2025 May.
Solitary fibrous tumor (SFT) is an uncommon mesenchymal neoplasm, rarely localized to the head and neck region. Due to its diverse morphological and histological characteristics, SFT may be misdiagnosed as other soft tissue sarcomas. This case report describes an atypical presentation of SFT involving the upper lip in a 75-year-old man. The only non-specific clinical symptom was localized swelling. An intraoral examination revealed a well-defined, exophytic soft lesion. Magnetic resonance imaging (MRI) revealed a heterogeneous, lobulated lesion with well-defined margins and marked contrast enhancement. The histopathological evaluation demonstrated a proliferation of spindle cells with low mitotic activity within the dense fibrous stroma. Immunohistochemical (IHC) analysis confirmed the diagnosis of benign SFT, showing strong positivity for STAT6, CD34, and Ki-67 markers. Surgical excision of the mass and subsequent histopathological examination of the resected specimen corroborated the initial diagnosis. The patient underwent a follow-up evaluation six months postoperatively, presenting with a fully healed surgical site and no signs of recurrence.
孤立性纤维瘤（SFT）是一种罕见的间叶性肿瘤，很少局限于头颈部区域。由于其多样的形态学和组织学特征，SFT可能被误诊为其他软组织肉瘤。本病例报告描述了一名75岁男性上唇SFT的非典型表现。唯一的非特异性临床症状是局部肿胀。口腔检查发现一个边界清晰的外生性软性病变。磁共振成像（MRI）显示一个边界清晰、分叶状、不均匀的病变，有明显的对比增强。组织病理学评估显示在致密的纤维基质内有低有丝分裂活性的梭形细胞增殖。免疫组织化学（IHC）分析证实为良性SFT诊断，显示STAT6、CD34和Ki-67标记物呈强阳性。肿块手术切除及切除标本随后的组织病理学检查证实了最初的诊断。患者术后6个月接受随访评估，手术部位完全愈合，无复发迹象。
