Alswilem Abdullah, Hassan Khaled K, Almomen Firas, Alruhaimi Batoul, Mohaimeed Amna, Almazrou Noura, Aljabab Saif, Alayed Yasir, Alsaeed Eyad, Alsuhaibani Abdullah
Oncology Center, King Saud University Medical City, Riyadh, SAU.
Kasr Al-Ainy Center of Clinical Oncology, Faculty of Medicine, Cairo University, Cairo, EGY.
Cureus. 2025 May 5;17(5):e83535. doi: 10.7759/cureus.83535. eCollection 2025 May.
Insulinomas are the most prevalent hormone-producing pancreatic neuroendocrine neoplasms (panNEN). Surgical resection of these tumors is frequently curative and is currently the mainstay treatment for preventing long-term brain damage caused by hypoglycemia. Stereotactic body radiation therapy (SBRT) is an external radiation therapy utilizing specific equipment for positioning patients and delivering a focused radiation dose to tumors in the body over a series of sessions while fostering minimal radiation exposure to surrounding healthy tissue. This report presents a six-year follow-up and comprehensive update of a previously published case of insulinoma treated with SBRT, including new imaging, biochemical outcomes, detailed SBRT planning methodology, and an updated literature review. These additions provide long-term insight into SBRT as a high-precision alternative for patients who decline or are unfit for surgery.
胰岛素瘤是最常见的产生激素的胰腺神经内分泌肿瘤（panNEN）。手术切除这些肿瘤通常可治愈，并且是目前预防低血糖导致长期脑损伤的主要治疗方法。立体定向体部放射治疗（SBRT）是一种外部放射治疗，它利用特定设备对患者进行定位，并在一系列疗程中向体内肿瘤输送聚焦的放射剂量，同时使周围健康组织受到的辐射暴露降至最低。本报告展示了一例先前发表的接受SBRT治疗的胰岛素瘤病例的六年随访及全面更新内容，包括新的影像学检查、生化结果、详细的SBRT计划方法以及最新的文献综述。这些补充内容为SBRT作为一种高精度替代方案用于拒绝手术或不适合手术的患者提供了长期见解。
