Myrehaug Sten, Hallet Julie, Chu William, Yong Elaine, Law Calvin, Assal Angela, Koshkina Olexandra, Louie Alexander V, Singh Simron
Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto. 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Department of Surgical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto. 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
J Radiosurg SBRT. 2020;6(4):321-324.
Dysregulated hormonal production remains a challenge in the management of neuroendocrine neoplasms (NEN). We report 4 cases of patients with functional NEN treated with stereotactic body radiation therapy (SBRT) to either the primary/dominant metastatic site of disease or the end organ of hormonal release. No significant toxicities were observed during or after treatment. Each patient has had biochemical, clinical and radiographic response to therapy, providing proof of concept that SBRT is an effective therapeutic strategy for functional neuroendocrine neoplasms.
激素分泌失调在神经内分泌肿瘤（NEN）的管理中仍然是一个挑战。我们报告了4例功能性NEN患者，他们接受了立体定向体部放疗（SBRT），治疗部位为疾病的原发/主要转移部位或激素释放的终末器官。治疗期间及治疗后均未观察到明显毒性。每位患者对治疗均有生化、临床和影像学反应，这为SBRT是功能性神经内分泌肿瘤的有效治疗策略提供了概念验证。
