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准分子灯联合外用2%托法替布凝胶治疗儿童斑秃:1例报告

Use of Excimer Lamp and Topical Tofacitinib 2% Gel in the Treatment of Pediatric Alopecia Areata: A Case Report.

作者信息

Dineshkumar Revathi, Manthri Shvedha, Duraisamy Swetha, Malvi Abhijeet

机构信息

Dermatology, Revathi Hospital, Salem, IND.

Medical Affairs, Eris Lifesciences Limited, Ahmedabad, IND.

出版信息

Cureus. 2025 May 5;17(5):e83492. doi: 10.7759/cureus.83492. eCollection 2025 May.

DOI:10.7759/cureus.83492
PMID:40470441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12135105/
Abstract

Alopecia areata (AA) is a chronic inflammatory disease distinguished by non-scarring alopecia. The latest evidence suggests it is a T cell-mediated autoimmune disease that manifests in genetically susceptible individuals. In contrast to adult-onset AA, clinical traits and treatment of pediatric AA have been investigated very little. We hereby report a pediatric case of recalcitrant AA treated with a 308 nm excimer lamp and topical tofacitinib 2% gel.

摘要

斑秃(AA)是一种以非瘢痕性脱发为特征的慢性炎症性疾病。最新证据表明,它是一种T细胞介导的自身免疫性疾病,在遗传易感性个体中表现出来。与成人斑秃相比,儿童斑秃的临床特征和治疗方法很少被研究。我们在此报告一例用308纳米准分子灯和2%托法替布凝胶局部治疗的儿童顽固性斑秃病例。

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本文引用的文献

1
Efficacy and Safety of Topical Tofacitinib for the Treatment of Alopecia Areata.局部用托法替布治疗斑秃的疗效与安全性。
Indian Dermatol Online J. 2024 Jun 26;15(4):624-629. doi: 10.4103/idoj.idoj_535_23. eCollection 2024 Jul-Aug.
2
Clinico-Epidemiological Profile of Childhood Alopecia Areata Along with Dermoscopic Correlation: A Cross-Section, Observational Study.儿童斑秃的临床流行病学特征及其皮肤镜相关性:一项横断面观察性研究。
Indian Dermatol Online J. 2021 Mar 2;12(2):250-257. doi: 10.4103/idoj.IDOJ_451_20. eCollection 2021 Mar-Apr.
3
Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients.
2%托法替布软膏,一种局部应用的Janus激酶抑制剂,用于斑秃治疗:一项针对10例患者的初步研究。
J Am Acad Dermatol. 2018 Feb;78(2):403-404.e1. doi: 10.1016/j.jaad.2017.10.043. Epub 2017 Nov 3.
4
308-nm Excimer Lamp for the Treatment of Alopecia Areata: Clinical Trial on 16 Cases.用于斑秃治疗的308纳米准分子灯:16例临床试验
Indian J Dermatol. 2013 Jul;58(4):326. doi: 10.4103/0019-5154.113954.
5
Epidermal langerhans cell depletion after artificial ultraviolet B irradiation of human skin in vivo: apoptosis versus migration.人体皮肤在体人工紫外线B照射后表皮朗格汉斯细胞的损耗:凋亡与迁移
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Topical immunotherapy in alopecia areata.斑秃的局部免疫疗法。
J Invest Dermatol. 1991 May;96(5):71S-72S. doi: 10.1111/1523-1747.ep12471884.