Shi Rui, Liu Fei, Qin Qihuang, Li Pinxue, Huo Ziqi, Zhou You, Jiang Chunyan
Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Beijing Research Institute of Traumatology and Orthopaedics, Beijing, China.
Front Bioeng Biotechnol. 2025 May 21;13:1565347. doi: 10.3389/fbioe.2025.1565347. eCollection 2025.
The rotator cuff tendon-bone interface exhibits a gradient histological composition, including graded mineral content and interwoven collagen fibers. Following rotator cuff injury repair, the lack of a compositional, structural, and functional gradient at the interface results in stress concentration and a high rate of postoperative re-tears. Piezoelectric materials, known for modulating cellular functions and promoting stem cell proliferation and differentiation, have garnered increasing attention in tissue repair applications.
In this study, a biomimetic piezoelectric patch with progressive compositional and structural variations was designed and fabricated. The patch, composed of gelatin/PLGA/nHA/BTO, integrates aligned and random fiber structures. The aligned layer mimics the tendon-side structure of the rotator cuff tendon-bone interface, while the random layer replicates the bone-side structure.
The bioinspired patch exhibits excellent biocompatibility. The piezoelectric signals generated under ultrasound stimulation can induce osteogenic and tenogenic differentiation of stem cells, as well as regulate M2 polarization of macrophages, thereby promoting the repair and regeneration of supraspinatus tendon injury in a rabbit model of rotator cuff injury.
This study highlights the potential of biomimetic piezoelectric patches in orthopedic rotator cuff repair and offers new possibilities for developing advanced materials to regenerate the rotator cuff tendon-bone interface.
肩袖肌腱 - 骨界面呈现出渐变的组织学组成，包括渐变的矿物质含量和交织的胶原纤维。肩袖损伤修复后，界面处缺乏组成、结构和功能梯度会导致应力集中和较高的术后再撕裂率。压电材料以调节细胞功能、促进干细胞增殖和分化而闻名，在组织修复应用中受到越来越多的关注。
在本研究中，设计并制造了一种具有渐进式组成和结构变化的仿生压电贴片。该贴片由明胶/聚乳酸 - 羟基乙酸共聚物/纳米羟基磷灰石/钛酸钡组成，整合了排列有序和随机的纤维结构。排列有序的层模拟肩袖肌腱 - 骨界面的肌腱侧结构，而随机层复制骨侧结构。
这种受生物启发的贴片具有优异的生物相容性。超声刺激下产生的压电信号可诱导干细胞的成骨和成腱分化，并调节巨噬细胞的M2极化，从而促进兔肩袖损伤模型中冈上肌腱损伤的修复和再生。
本研究突出了仿生压电贴片在骨科肩袖修复中的潜力，并为开发用于再生肩袖肌腱 - 骨界面的先进材料提供了新的可能性。
