da Nóbrega Débora Nascimento, Barreto Ana Virgínia Matos Sá, Dos Santos Souza Roberta, do Ó Kleyton Palmeira, de Lima Raul Emídio, Domingues Ana Lúcia Coutinho, Lopes Edmundo Pessoa, de Morais Clarice Neuenschwander Lins, Gomes Elainne Christine de Souza, Vasconcelos Luydson Richardson Silva
Instituto Aggeu Magalhães (IAM/Fiocruz), Recife, Pernambuco, Brazil.
Centro Universitário Maurício de Nassau (UNINASSAU), Recife, Pernambuco, Brazil.
Parasite Immunol. 2025 Jun;47(6):e70011. doi: 10.1111/pim.70011.
Mir-10a acts in signalling pathways regulating transcription, translation, and RNA-mediated gene silencing, while IFNG acts in the T-cell receptor signalling pathway. Thus, both can be considered potential targets for understanding regulatory processes in chronic inflammation in patients with schistosomiasis. Populations in endemic areas receive mass and indiscriminate praziquantel treatment, and yet patients often have a history of multiple infections. To investigate the regulatory and prognostic capacity of miR-10 and IFNG in patient immunity, we evaluated the expression of miR-10a and IFNG as biomarkers of inflammation and their correlation with praziquantel treatment. miR-10a did not present evidence as a biomarker of inflammation in the therapeutic follow-up in schistosomiasis. However, the levels of IFNG expression were significantly higher before treatment.
Mir-10a在调节转录、翻译和RNA介导的基因沉默的信号通路中发挥作用，而IFNG在T细胞受体信号通路中发挥作用。因此，二者均可被视为理解血吸虫病患者慢性炎症调节过程的潜在靶点。流行地区的人群接受大规模且不加区分的吡喹酮治疗，但患者往往有多次感染史。为了研究miR-10和IFNG在患者免疫中的调节和预后能力，我们评估了miR-10a和IFNG作为炎症生物标志物的表达及其与吡喹酮治疗的相关性。在血吸虫病治疗随访中，miR-10a未表现出作为炎症生物标志物的证据。然而，治疗前IFNG的表达水平显著更高。
