"Pupdates" on proteasomal degradation in bacteria.

Proteasomes are multi-subunit proteases found in all domains of life. The central components of proteasomal degradation are conserved, but how proteins are targeted to proteasomes diverges significantly. Despite the vast amount of information learned about how proteasomal degradation is regulated in eukaryotes, much less is known about the regulation of proteasome activity in bacteria. In this minireview, we highlight recent findings revealing how and when specific proteins are targeted to bacterial proteasomes, with a focus on ATP-dependent proteolysis.