Schweitzer Ronny, de Marvao Antonio, Shah Mit, Inglese Paolo, Kellman Peter, Berry Alaine, Statton Ben, O'Regan Declan P
MRC Laboratory of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Department of Women and Children's Health, King's College London, London, United Kingdom.
Radiol Cardiothorac Imaging. 2025 Jun;7(3):e240175. doi: 10.1148/ryct.240175.
Purpose To evaluate the effects of exercise on left ventricular parameters using exercise cardiac MRI in healthy adults without known cardiovascular disease and establish reference ranges stratified by age and sex. Materials and Methods This prospective study included healthy adult participants with no known cardiovascular disease or genetic variants associated with cardiomyopathy, enrolled between January 2018 and April 2021, who underwent exercise cardiac MRI evaluation. Participants were imaged at rest and after exercise, and parameters were measured by two readers. Prediction intervals were calculated and compared across sex and age groups. Results The study included 161 participants (mean age, 49 years ± 14 [SD]; 85 female). Compared with the resting state, exercise caused an increase in heart rate (64 beats per minute ± 9 vs 133 beats per minute ± 19, < .001), left ventricular end-diastolic volume (140 mL ± 32 vs 148 mL ± 35, < .001), stroke volume (82 mL ± 18 vs 102 mL ± 25, < .001), ejection fraction (59% ± 6 vs 69% ± 7, < .001), and cardiac output (5.2 L/min ± 1.1 vs 13.5 L/min ± 3.9, < .001) and a decrease in left ventricular end-systolic volume (58 mL ± 18 vs 46 mL ± 15, < .001). There were statistically significant differences in exercise response between groups stratified by sex and age for most parameters. Conclusion In healthy adults, an increase in cardiac output after exercise was driven by an increase in heart rate with both increased ventricular filling and emptying. Normal ranges for exercise response, stratified by age and sex, were established as a reference for the use of exercise cardiac MRI in clinical practice. Cardiac, MR Imaging, Heart, Physiological Studies © RSNA, 2025.
目的 使用运动心脏磁共振成像评估运动对无已知心血管疾病的健康成年人左心室参数的影响，并建立按年龄和性别分层的参考范围。材料与方法 这项前瞻性研究纳入了2018年1月至2021年4月期间招募的无已知心血管疾病或与心肌病相关的基因变异的健康成年参与者，他们接受了运动心脏磁共振成像评估。参与者在静息和运动后进行成像，参数由两名阅片者测量。计算预测区间并在性别和年龄组之间进行比较。结果 该研究包括161名参与者（平均年龄49岁±14[标准差]；85名女性）。与静息状态相比，运动导致心率增加（每分钟64次±9次对每分钟133次±19次，P<.001）、左心室舒张末期容积增加（140 mL±32对148 mL±35，P<.001）、每搏输出量增加（82 mL±18对102 mL±25，P<.001）、射血分数增加（59%±6对69%±7，P<.001）、心输出量增加（5.2 L/分钟±1.1对13.5 L/分钟±3.9，P<.001）以及左心室收缩末期容积减少（58 mL±18对46 mL±15，P<.001）。在按性别和年龄分层的组之间，大多数参数的运动反应存在统计学显著差异。结论 在健康成年人中，运动后心输出量的增加是由心率增加驱动的，同时心室充盈和排空均增加。建立按年龄和性别分层的运动反应正常范围作为运动心脏磁共振成像在临床实践中应用的参考。心脏、磁共振成像、心脏、生理学研究 © RSNA，2025年
