血红蛋白与2型糖尿病肾病的相关性分析：一项两中心回顾性研究
Correlation analysis between hemoglobin and type 2 diabetic nephropathy: a two-center retrospective study.
作者信息
Liu Xiaoling, Zhang Ze, Lin Lu, Li Jinghui, Liu Bende, Xu Xiangjin, Chen Huaqian, Zhou Junwei, Chen Pin
机构信息
Fuzong Clinical Medical College of Fujian Medical University, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, China.
Department of Nephrology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, China.
出版信息
Acta Diabetol. 2025 Jun 5. doi: 10.1007/s00592-025-02529-9.
OBJECTIVE
This study aimed to investigate the relationship between hemoglobin (Hb) levels and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).
METHODS
We recruited patients with T2DM from two centers, collected their clinical data, and analyzed the relationship between Hb levels and DN using binary logistic regression analysis and restricted cubic spline squares (RCS) plots.
RESULTS
A total of 1956 patients with T2DM were enrolled, including 784 (40.1%) with DN. After adjusting for several confounding factors, the proportion of patients with DN in Q1 of Hb was significantly higher than that in the other group. The RCS curve revealed that Hb levels were inversely proportional to DN. Subgroup analysis demonstrated that age, gender, history of hypertension, history of nonalcoholic fatty liver disease and history of diabetic retinopathy exhibited no significant correlation with Hb levels and DN.
CONCLUSIONS
Low Hb level is closely associated with DN occurrence, and can be used as a predictive biomarker for DN.
目的
本研究旨在探讨2型糖尿病（T2DM）患者血红蛋白（Hb）水平与糖尿病肾病（DN）之间的关系。
方法
我们从两个中心招募了T2DM患者，收集他们的临床数据，并使用二元逻辑回归分析和受限立方样条平方（RCS）图分析Hb水平与DN之间的关系。
结果
共纳入1956例T2DM患者，其中784例（40.1%）患有DN。在调整了几个混杂因素后，Hb处于第一四分位数的患者中DN的比例显著高于另一组。RCS曲线显示Hb水平与DN呈负相关。亚组分析表明，年龄、性别、高血压病史、非酒精性脂肪性肝病病史和糖尿病视网膜病变病史与Hb水平和DN无显著相关性。
结论
低Hb水平与DN的发生密切相关，可作为DN的预测生物标志物。
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