Chen Mengdie, Wang Yiyun, Feng Ping, Wu Lijing, Liu Hanying, Liang Yao, Yang Mengyao, Zheng Qidong
Department of Endocrinology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.
Department of Internal Medicine, Yuhuan Second People's Hospital, Yuhuan, China.
Front Endocrinol (Lausanne). 2025 Jun 19;16:1553890. doi: 10.3389/fendo.2025.1553890. eCollection 2025.
Early-onset type 2 diabetes mellitus (T2DM) is closely associated with an increased risk of diabetic kidney disease (DKD), and obesity is a well-recognized contributing factor. Traditional measures like body mass index (BMI) have limitations in capturing visceral fat distribution. The A Body Shape Index (ABSI), a newer anthropometric indicator, may provide a more accurate assessment of central obesity. This study investigated the relationship between ABSI and DKD in individuals with early-onset T2DM.
This cross-sectional study analyzed data from 2,598 patients with early-onset T2DM enrolled at the National Metabolic Management Centers of Yuhuan Second People's Hospital and Taizhou Central Hospital between 2017 and 2024. Multivariate logistic regression models were used to evaluate the association between ABSI and DKD, with additional analyses using restricted cubic splines (RCS) to explore dose-response patterns. Subgroup and interaction analyses were also performed.
Of the participants, 1,030 (39.6%) were diagnosed with DKD. The prevalence of DKD increased across ABSI tertiles: 35.8% in the lowest tertile (T1), 38.5% in the middle tertile (T2), and 44.7% in the highest tertile (T3) (P < 0.001). Higher ABSI was independently associated with a greater risk of DKD (OR = 1.24; 95% CI: 1.05-1.50; P = 0.022) after adjusting for potential confounders. Patients in the highest ABSI tertile had a significantly higher risk of DKD than those in the lowest tertile (OR = 1.24; 95% CI: 1.01-1.52; P = 0.041). RCS analysis showed a positive linear relationship between ABSI and DKD risk (P for non-linearity = 0.139), and the findings were consistent across subgroups.
ABSI is positively and linearly associated with the risk of DKD in patients with early-onset T2DM. This metric may be useful for identifying individuals at higher risk and guiding early preventive strategies.
早发型2型糖尿病（T2DM）与糖尿病肾病（DKD）风险增加密切相关，肥胖是一个公认的促成因素。诸如体重指数（BMI）等传统指标在反映内脏脂肪分布方面存在局限性。体型指数（ABSI）作为一种较新的人体测量指标，可能能更准确地评估中心性肥胖。本研究调查了早发型T2DM患者中ABSI与DKD之间的关系。
这项横断面研究分析了2017年至2024年期间在玉环市第二人民医院和台州市中心医院国家代谢管理中心登记的2598例早发型T2DM患者的数据。使用多变量逻辑回归模型评估ABSI与DKD之间的关联，并使用受限立方样条（RCS）进行额外分析以探索剂量反应模式。还进行了亚组分析和交互分析。
在参与者中，1030例（39.6%）被诊断为DKD。DKD的患病率在ABSI三分位数中呈上升趋势：最低三分位数（T1）为35.8%，中间三分位数（T2）为38.5%，最高三分位数（T3）为44.7%（P<0.001）。在调整潜在混杂因素后，较高的ABSI与DKD风险增加独立相关（OR=1.24；95%CI：1.05-1.50；P=0.022）。ABSI最高三分位数的患者患DKD的风险显著高于最低三分位数的患者（OR=1.24；95%CI：1.01-1.52；P=0.041）。RCS分析显示ABSI与DKD风险之间存在正线性关系（非线性P=0.139），且该结果在各亚组中一致。
ABSI与早发型T2DM患者的DKD风险呈正线性相关。该指标可能有助于识别高危个体并指导早期预防策略。
