Shohrati Majid, Abedi Farshad, Bagheri Mahdi, Sahebkar Amirhossein
Department of Clinical Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmacol Rep. 2025 Jun 5. doi: 10.1007/s43440-025-00744-3.
Vascular smooth muscle cells (SMCs) are pivotal in regulating vascular tone and integrity. Their dysregulation significantly contributes to the pathophysiology of cardiovascular ailments, including atherosclerosis, blood pressure, and vascular remodeling. Curcumin, a polyphenol with a natural origin in turmeric, exhibits promising therapeutic properties due to its remarkable anti-inflammatory, antioxidant, and antiproliferative characteristics. This review aims to assess the effects of curcumin on vascular SMC behavior, encompassing its impact on proliferation, migration, phenotypic switching, and extracellular matrix remodeling. The underlying molecular mechanisms are highlighted, particularly curcumin's modulation of signaling pathways such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and nuclear transcription factor E2-related factor-2 (Nrf2) signaling pathways, as well as its ability to decrease oxidative stress and inflammatory cytokine generation. Furthermore, we evaluate the implications of the results for vascular health and disease, emphasizing curcumin's potential to prevent or mitigate atherosclerosis, restenosis, and hypertension. Despite promising preclinical evidence, challenges related to curcumin's bioavailability and clinical translation remain.
血管平滑肌细胞（SMC）在调节血管张力和完整性方面起着关键作用。它们的失调显著促成了心血管疾病的病理生理学过程，包括动脉粥样硬化、血压异常和血管重塑。姜黄素是一种源自姜黄的天然多酚，因其具有显著的抗炎、抗氧化和抗增殖特性而展现出有前景的治疗特性。本综述旨在评估姜黄素对血管平滑肌细胞行为的影响，包括其对增殖、迁移、表型转换和细胞外基质重塑的影响。重点阐述了潜在的分子机制，特别是姜黄素对核因子-κB（NF-κB）、丝裂原活化蛋白激酶（MAPK）和核转录因子E2相关因子2（Nrf2）等信号通路的调节作用，以及其降低氧化应激和炎症细胞因子生成的能力。此外，我们评估了这些结果对血管健康和疾病的意义，强调了姜黄素在预防或减轻动脉粥样硬化、再狭窄和高血压方面的潜力。尽管临床前证据很有前景，但与姜黄素的生物利用度和临床转化相关的挑战依然存在。
