Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410011, China; Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
J Control Release. 2024 Sep;373:640-651. doi: 10.1016/j.jconrel.2024.07.067. Epub 2024 Aug 1.
Bone metastasis, a prevalent occurrence in primary malignant tumors, is often associated with a grim prognosis. The bone microenvironment comprises various coexisting cell types, working together in a coordinated manner. This dynamic microenvironment plays a pivotal role in the initiation and progression of bone metastases. While cancer therapies have made advancements, the available options for addressing bone metastases remain insufficient. The advent of nanotechnology has ushered in a new era for managing and preventing bone metastases because of the physicochemical and adaptable advantages of nanoplatforms. In this review, we make an introduction of the underlying mechanisms and the current clinical therapies of bone metastases, highlighting the advances of intelligent nanosystems that can stimulate vascular regeneration, promote bone regeneration, eliminate tumor cells, minimize bone damage, and expedite bone healing. The innovation surrounding bone-targeting nanoplatforms presents a fresh approach to the theranostics of bone metastases.
骨转移是原发性恶性肿瘤的常见现象，常伴有预后不良。骨微环境包含各种共存的细胞类型，它们协同工作。这种动态微环境在骨转移的发生和进展中起着关键作用。尽管癌症治疗取得了进展，但针对骨转移的治疗选择仍然不足。纳米技术的出现为管理和预防骨转移带来了一个新时代，因为纳米平台具有物理化学和适应性优势。在这篇综述中，我们介绍了骨转移的潜在机制和当前的临床治疗方法，强调了智能纳米系统的进展，这些系统可以刺激血管再生、促进骨再生、消除肿瘤细胞、最小化骨损伤和加速骨愈合。骨靶向纳米平台的创新为骨转移的治疗提供了一种新方法。
