Li Ke-Xue, Wang Zi-Chao, Machuki Jeremiah Ong'Achwa, Li Meng-Zhen, Wu Yu-Jie, Niu Ming-Kai, Yu Kang-Ying, Lu Qing-Bo, Sun Hai-Jian
Department of Physiology, Xuzhou Medical University, Xuzhou, China.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Front Physiol. 2022 Apr 1;13:848867. doi: 10.3389/fphys.2022.848867. eCollection 2022.
Growing evidence suggests that hypertension is one of the leading causes of cardiovascular morbidity and mortality since uncontrolled high blood pressure increases the risk of myocardial infarction, aortic dissection, hemorrhagic stroke, and chronic kidney disease. Impaired vascular homeostasis plays a critical role in the development of hypertension-induced vascular remodeling. Abnormal behaviors of vascular cells are not only a pathological hallmark of hypertensive vascular remodeling, but also an important pathological basis for maintaining reduced vascular compliance in hypertension. Targeting vascular remodeling represents a novel therapeutic approach in hypertension and its cardiovascular complications. Phytochemicals are emerging as candidates with therapeutic effects on numerous pathologies, including hypertension. An increasing number of studies have found that curcumin, a polyphenolic compound derived from dietary spice turmeric, holds a broad spectrum of pharmacological actions, such as antiplatelet, anticancer, anti-inflammatory, antioxidant, and antiangiogenic effects. Curcumin has been shown to prevent or treat vascular remodeling in hypertensive rodents by modulating various signaling pathways. In the present review, we attempt to focus on the current findings and molecular mechanisms of curcumin in the treatment of hypertensive vascular remodeling. In particular, adverse and inconsistent effects of curcumin, as well as some favorable pharmacokinetics or pharmacodynamics profiles in arterial hypertension will be discussed. Moreover, the recent progress in the preparation of nano-curcumins and their therapeutic potential in hypertension will be briefly recapped. The future research directions and challenges of curcumin in hypertension-related vascular remodeling are also proposed. It is foreseeable that curcumin is likely to be a therapeutic agent for hypertension and vascular remodeling going forwards.
越来越多的证据表明，高血压是心血管疾病发病和死亡的主要原因之一，因为未得到控制的高血压会增加心肌梗死、主动脉夹层、出血性中风和慢性肾病的风险。血管稳态受损在高血压诱导的血管重塑发展过程中起着关键作用。血管细胞的异常行为不仅是高血压性血管重塑的病理标志，也是维持高血压状态下血管顺应性降低的重要病理基础。针对血管重塑是高血压及其心血管并发症的一种新型治疗方法。植物化学物质正成为对包括高血压在内的多种疾病具有治疗作用的候选物质。越来越多的研究发现，姜黄素这种从膳食香料姜黄中提取的多酚类化合物具有广泛的药理作用，如抗血小板、抗癌、抗炎、抗氧化和抗血管生成作用。姜黄素已被证明可通过调节各种信号通路预防或治疗高血压啮齿动物的血管重塑。在本综述中，我们试图聚焦于姜黄素治疗高血压性血管重塑的当前研究结果和分子机制。特别是，将讨论姜黄素的不良和不一致效应，以及其在动脉高血压中的一些有利的药代动力学或药效学特征。此外，还将简要回顾纳米姜黄素制备的最新进展及其在高血压治疗中的潜力。还提出了姜黄素在高血压相关血管重塑方面未来的研究方向和挑战。可以预见，姜黄素未来可能成为治疗高血压和血管重塑的药物。
