Fernandez Maria Emilia, Bernier Michel, Price Nathan L, Camandola Simonetta, Aon Miguel A, Vaughan Kelli, Mattison Julie A, Preston Joshua D, Jones Dean P, Tanaka Toshiko, Tian Qu, González-Freire Marta, Ferrucci Luigi, de Cabo Rafael
Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health (NIH), Baltimore, MD, USA.
Laboratory of Cardiovascular Sciences, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.
Science. 2025 Jun 5;388(6751):eadl2116. doi: 10.1126/science.adl2116.
Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman primates and mice when measured longitudinally (repeatedly in the same population) or cross-sectionally (sampling distinct populations at various ages). Moreover, considerable variability was observed in associations between taurine and age-related changes in health outcomes pertaining to gross motor function and energy homeostasis. Our results suggest that changes in circulating taurine are not a universal feature of aging and that its pleiotropic effects may be dependent on the temporal and physiological context of each individual.
低循环牛磺酸浓度被认为是衰老过程的一个驱动因素。我们发现，在三个地理位置不同的人类队列以及非人类灵长类动物和小鼠中，当纵向（在同一群体中重复测量）或横向（在不同年龄对不同群体进行采样）测量时，循环牛磺酸浓度会随着年龄增长而增加或保持不变。此外，在牛磺酸与与总体运动功能和能量稳态相关的健康结果的年龄相关变化之间的关联中观察到了相当大的变异性。我们的结果表明，循环牛磺酸的变化并非衰老的普遍特征，其多效性作用可能取决于每个个体的时间和生理背景。
