Bhargava Divya, Chowdhury Aniqa, Dube Danielle H
Department of Chemistry and Biochemistry, Bowdoin College, 6600 College Station, Brunswick, ME 04011, USA.
Department of Chemistry and Biochemistry, Bowdoin College, 6600 College Station, Brunswick, ME 04011, USA.
Curr Opin Chem Biol. 2025 Jun 4;87:102603. doi: 10.1016/j.cbpa.2025.102603.
Glycans cover the surfaces of all cells, where they are poised to mediate a two-way discourse between bacteria and host cells. In some instances, glycan-mediated interactions foster a symbiotic state, and in others, they tip the balance toward disease. Chemical biology approaches have begun to reveal the roles of glycans in host-bacteria interactions and provide novel pathways to modulate these interactions. Here, we highlight recent advances in the development and application of chemical biology tools to delineate the roles of glycans in bacterial adhesion, bacterial evasion of the host immune system, host recognition of bacterial cells, and endogenous mechanisms to maintain symbiosis. Further, we present glycan-based strategies to disrupt host-pathogen interactions and to promote the growth of beneficial bacteria.
聚糖覆盖所有细胞的表面，在那里它们随时准备介导细菌与宿主细胞之间的双向交流。在某些情况下，聚糖介导的相互作用促进共生状态，而在其他情况下，则会使平衡向疾病方向倾斜。化学生物学方法已开始揭示聚糖在宿主-细菌相互作用中的作用，并提供调节这些相互作用的新途径。在这里，我们重点介绍化学生物学工具在开发和应用方面的最新进展，以阐明聚糖在细菌黏附、细菌逃避宿主免疫系统、宿主对细菌细胞的识别以及维持共生的内源性机制中的作用。此外，我们还介绍了基于聚糖的策略，以破坏宿主-病原体相互作用并促进有益细菌的生长。
