Zhang Mengyao, Hu Xin, Huang Yudai
State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University, Urumqi, Xinjiang 830017, PR China.
College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, Guangdong 518118, PR China.
Colloids Surf B Biointerfaces. 2025 Oct;254:114835. doi: 10.1016/j.colsurfb.2025.114835. Epub 2025 May 30.
Compared to the first near-infrared (NIR-I) window (650-1000 nm), the second near-infrared (NIR-II) window (1000-1700 nm) is more valuable for photothermal treatment (PTT) due to its deeper tissue penetration and lower phototoxicity. However, the therapeutic efficacy of PTT remains suboptimal owing to the inherently low photothermal conversion efficiency (PCE) of existing materials. Therefore, the development of nanomaterials with high PCE is a promising strategy for improving anti-tumor therapy. In this study, hollow semimetal PtTe nanorods were synthesized. Their unique electronic properties and hollow structure contribute to achieving high PCE under NIR-II irradiation, while simultaneously promoting reactive oxygen species (ROS) generation. Additionally, PtTe catalyzed the endogenous conversion of hydrogen peroxide (HO) into oxygen (O) and hydroxyl radicals (•OH), further enhancing anti-tumor effects via chemodynamic therapy (CDT). In vivo experiments confirmed the excellent biocompatibility of PtTe, and laser treatment following PtTe administration significantly inhibited tumor growth, demonstrating its favorable therapeutic efficacy. This study establishes a new nanoplatform for the treatment of malignant tumors through photothermal/photodynamic/chemodynamic therapy, providing valuable insights for future research on multifunctional cancer therapies.
与第一近红外（NIR-I）窗口（650 - 1000纳米）相比，第二近红外（NIR-II）窗口（1000 - 1700纳米）因其更深的组织穿透深度和更低的光毒性，在光热治疗（PTT）中更具价值。然而，由于现有材料固有的低光热转换效率（PCE），PTT的治疗效果仍然不尽人意。因此，开发具有高PCE的纳米材料是改善抗肿瘤治疗的一种有前景的策略。在本研究中，合成了中空半金属PtTe纳米棒。它们独特的电子性质和中空结构有助于在NIR-II照射下实现高PCE，同时促进活性氧（ROS）的产生。此外，PtTe催化过氧化氢（HO）内源性转化为氧气（O）和羟基自由基（•OH），通过化学动力学疗法（CDT）进一步增强抗肿瘤效果。体内实验证实了PtTe具有优异的生物相容性，给药后进行激光治疗显著抑制了肿瘤生长，证明了其良好的治疗效果。本研究通过光热/光动力/化学动力学疗法建立了一种治疗恶性肿瘤的新型纳米平台，为未来多功能癌症治疗的研究提供了有价值的见解。
