Ye Yu, Zeng Xiangchen, Luo Zhong, Gan Wenxuan, Dang Yongying, Yang Shuoqi, Zhang Yuxiang, Qiu Xingfeng, Zhang Tong, Du Zhenshuang, Wang Peiyuan, He Weiling
Department of Gastrointestinal Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361000, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian 361000, China.
J Colloid Interface Sci. 2025 Nov 15;698:138094. doi: 10.1016/j.jcis.2025.138094. Epub 2025 Jun 5.
Hollow mesoporous manganese (HMM)-based nanocarriers, incorporating nanoparticle cavities and mesoporous channels, enhance the photostability and photobleaching resistance of indocyanine green (ICG). The addition of H2N-c(RGDfK)-OH (RGD) ensures precise targeting, making the cRGD&PEG2000-HMM@ICG (R&P-M@ICG) nanoprobe ideal for NIR-II fluorescence image-guided surgery and photothermal therapy (PTT). This approach offers accurate targeting, high therapeutic efficacy, and reduced side effects. The inclusion of manganese (Mn) in the nanocarriers further boosts the therapeutic effects by enabling chemodynamic therapy (CDT). Mn ions catalyze the conversion of hydrogen peroxide (HO) into highly reactive hydroxyl radicals (•OH) within the tumor microenvironment. The synergy between Mn-driven CDT and PTT enhances tumor ablation, as the heat from PTT accelerates ROS production from CDT, leading to more effective tumor cell damage and apoptosis. The dual action of PTT and CDT overcomes the limitations of single-modal therapies. While PTT induces hyperthermia to kill tumor cells, Mn-assisted CDT amplifies the ROS generation, further enhancing treatment efficacy. This combined effect makes the R&P-M@ICG nanoprobe a powerful tool for cancer treatment, demonstrating superior anti-tumor efficacy compared to conventional therapies. In this study, we synthesized the R&P-M@ICG nanoprobe, highlighting its potential for precise surgical navigation, and for synergistic photothermal and chemodynamic therapy in cancer treatment.
基于中空介孔锰（HMM）的纳米载体，兼具纳米颗粒空腔和介孔通道，可增强吲哚菁绿（ICG）的光稳定性和抗光漂白性。添加H2N-c(RGDfK)-OH（RGD）可确保精准靶向，使cRGD&PEG2000-HMM@ICG（R&P-M@ICG）纳米探针成为近红外二区荧光图像引导手术和光热疗法（PTT）的理想选择。这种方法具有精准靶向、高治疗效果和减少副作用的特点。纳米载体中包含的锰（Mn）通过实现化学动力学疗法（CDT）进一步提高治疗效果。锰离子在肿瘤微环境中催化过氧化氢（HO）转化为高活性羟基自由基（•OH）。锰驱动的CDT与PTT之间的协同作用增强了肿瘤消融效果，因为PTT产生的热量加速了CDT产生ROS，导致更有效的肿瘤细胞损伤和凋亡。PTT和CDT的双重作用克服了单模态疗法的局限性。PTT通过诱导热疗杀死肿瘤细胞，而锰辅助的CDT则增强了ROS的产生，进一步提高了治疗效果。这种联合效应使R&P-M@ICG纳米探针成为癌症治疗的有力工具，与传统疗法相比显示出卓越的抗肿瘤疗效。在本研究中，我们合成了R&P-M@ICG纳米探针，突出了其在精确手术导航以及癌症治疗中光热和化学动力学协同治疗方面的潜力。
