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Biosynthesis and insertion of Wolfgram protein into optic nerve membranes.

作者信息

Karin N J, Waehneldt T V

出版信息

Neurochem Res. 1985 Jul;10(7):897-907. doi: 10.1007/BF00964627.

DOI:10.1007/BF00964627
PMID:4047284
Abstract

Antibodies against pig brain Wolfgram protein (WP) were prepared and utilized in the analysis of WP biosynthesis in membranes from optic nerves of 20 day-old rats. Newly synthesized WP appeared rapidly (less than 5 min) in myelin and in a non-myelin microsome fraction and accumulated in both thereafter. Monensin did not affect the insertion of WP in either membrane fraction. These results are consistent with biosynthesis of WP on free ribosomes.

摘要

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引用本文的文献

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本文引用的文献

1
Nervous system myelin in the electric ray, Torpedo marmorata: Morphological characterization of the membrane and biochemical analysis of its protein components.电鳐（Torpedo marmorata）的神经系统髓磷脂：膜的形态学特征及其蛋白质成分的生化分析
Neurochem Int. 1984;6(2):223-35. doi: 10.1016/0197-0186(84)90097-4.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Intracellular translocation of newly synthesized myelin proteins in the rat brain stem slices.
地高辛标记探针原位杂交：应用于大鼠脑髓鞘形成的灵敏可靠检测方法
Acta Neuropathol. 1992;84(6):581-7. doi: 10.1007/BF00227734.
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The Golgi complex: crossroads for vesicular traffic.高尔基体：囊泡运输的枢纽
Int Rev Exp Pathol. 1980;22:227-51.
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Comparative electrophoretic study of the Wolfgram proteins in myelin from several mammalia.
Brain Res. 1980 May 12;189(2):582-7. doi: 10.1016/0006-8993(80)90373-x.
6
Peripheral nervous system myelin assembly in vitro: perturbation by the ionophore monensin.体外周围神经系统髓鞘组装：离子载体莫能菌素的干扰作用
J Neurochem. 1983 Aug;41(2):426-33. doi: 10.1111/j.1471-4159.1983.tb04759.x.
7
Effects of monensin on posttranslational processing of myelin proteins.莫能菌素对髓鞘蛋白翻译后加工的影响。
J Neurochem. 1983 May;40(5):1333-9. doi: 10.1111/j.1471-4159.1983.tb13575.x.
8
Surface labelling of oligodendrocytes with anti-myelin serum in cell cultures from the rat brain. Light- and electron-microscopic immunocytochemical studies.用抗髓磷脂血清对大鼠脑组织细胞培养物中的少突胶质细胞进行表面标记。光镜和电镜免疫细胞化学研究。
Cell Tissue Res. 1982;225(3):581-94. doi: 10.1007/BF00214806.
9
Immunofluorescence demonstration of 2':3'-cyclic-nucleotide 3'-phosphodiesterase in cultured oligodendrocytes of mouse, rat, calf and human.
Brain Res. 1984 May 21;300(1):195-9. doi: 10.1016/0006-8993(84)91360-x.
10
Characterization of 2':3'-cyclic nucleotide 3'-phosphodiesterase: limited proteolytic digestion, plant lectin affinity chromatography, and immunological identification.
J Neurochem. 1981 Jun;36(6):2004-12. doi: 10.1111/j.1471-4159.1981.tb10826.x.