阿尔茨海默病中红细胞膜胆碱外流速率增加的证据。

Evidence for an increased rate of choline efflux across erythrocyte membranes in Alzheimer's disease.

作者信息

Butterfield D A, Nicholas M M, Markesbery W R

出版信息

Neurochem Res. 1985 Jul;10(7):909-18. doi: 10.1007/BF00964628.

Abstract

Alzheimer's disease (AD), the major dementing disorder of the elderly, is associated with cholinergic neuronal loss and decreased activity of choline acetyltransferase (CAT). Previous biophysical studies had suggested an altered conformation of membrane proteins in AD erythrocyte ghosts. Since erythrocytes have a choline transport system and cholinergic neurons are implicated in AD, the present experiments were undertaken to determine if the efflux rate of [14C]choline was altered in AD erythrocytes. The mean efflux rate constant was highly significantly increased (P less than 0.01) by greater than 25% in 9 drug-free AD patients compared to 9 sex-matched, drug-free controls of similar age. These results are discussed in terms of potential molecular mechanisms to account for cholinergic neuronal loss in AD.

摘要

阿尔茨海默病（AD）是老年人主要的痴呆症，与胆碱能神经元丧失及胆碱乙酰转移酶（CAT）活性降低有关。先前的生物物理学研究表明，AD红细胞膜蛋白构象发生改变。由于红细胞具有胆碱转运系统，且胆碱能神经元与AD有关，因此进行了本实验，以确定AD患者红细胞中[14C]胆碱的流出率是否改变。与9名年龄相仿、性别匹配且未服用药物的对照组相比，9名未服用药物的AD患者的平均流出速率常数显著升高（P<0.01），增幅超过25%。本文从潜在分子机制的角度对这些结果进行了讨论，以解释AD中胆碱能神经元丧失的原因。