红细胞胆碱。I：阿尔茨海默病中的胆碱。

Red blood cell choline. I: Choline in Alzheimer's disease.

作者信息

Greenwald B S, Edasery J, Mohs R C, Shah N, Trigos G G, Davis K L

出版信息

Biol Psychiatry. 1985 Apr;20(4):367-74. doi: 10.1016/0006-3223(85)90039-3.

Abstract

Seventeen drug-free patients with Alzheimer's disease (AD) and 15 normal elderly controls, of which 13 age- and sex-matched pairs were included, participated in a study of red blood cell (RBC) and plasma choline. Mean values for RBC choline, plasma choline, and the ratio of RBC/plasma choline did not differ between the AD and control groups. Degree of dementia did not correlate with any blood choline measure. A correlation was found between age and RBC choline (r = 0.57; p less than or equal to 0.01) and the RBC/plasma choline ratio (r = 0.56; p less than or equal to 0.03) in normals, but not in AD patients. RBC choline correlated with plasma choline in AD patients only (r = 0.46, p less than or equal to 0.03). These results do not support the use of RBC and plasma choline concentrations as either a diagnostic tool to identify AD patients or an antemortem index of the cholinergic deficit in brains of patients with Alzheimer's disease.

摘要

17名未服用药物的阿尔茨海默病（AD）患者和15名正常老年对照者（其中包括13对年龄和性别匹配的对子）参与了一项关于红细胞（RBC）和血浆胆碱的研究。AD组和对照组之间的RBC胆碱、血浆胆碱以及RBC/血浆胆碱比值的平均值没有差异。痴呆程度与任何血液胆碱指标均无相关性。在正常人群中，年龄与RBC胆碱（r = 0.57；p≤0.01）以及RBC/血浆胆碱比值（r = 0.56；p≤0.03）之间存在相关性，但在AD患者中未发现这种相关性。仅在AD患者中，RBC胆碱与血浆胆碱相关（r = 0.46，p≤0.03）。这些结果不支持将RBC和血浆胆碱浓度用作识别AD患者的诊断工具或阿尔茨海默病患者脑内胆碱能缺陷的生前指标。