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对人类腹侧前脑离散胆碱能核的研究。

A search for discrete cholinergic nuclei in the human ventral forebrain.

作者信息

Davies P, Feisullin S

出版信息

J Neurochem. 1982 Dec;39(6):1743-7. doi: 10.1111/j.1471-4159.1982.tb08013.x.

DOI:10.1111/j.1471-4159.1982.tb08013.x
PMID:7143002
Abstract

Slices cut from five frozen human brains were dissected into 2-mm cubes and assayed for choline acetyltransferase (ChAT) activity and protein content. A pattern of enrichment of ChAT activity was found ventral to the anterior commissure; this finding is consistent with the location of the enzyme in the cells of the nucleus basalis of Meynert. The region beneath the anterior commissure was the only place a discrete enrichment of activity could be found, and the precise topography of the enrichment was somewhat variable from brain to brain. The results are discussed in the light of recent knowledge concerning the source of the cortical cholinergic innervation.

摘要

从五个冷冻人脑切下的切片被切成2毫米的立方体,并检测其胆碱乙酰转移酶(ChAT)活性和蛋白质含量。在胼胝体前联合腹侧发现了ChAT活性增强的模式;这一发现与该酶在Meynert基底核细胞中的位置一致。胼胝体前联合下方的区域是唯一能发现活性离散增强的地方,而且不同大脑中这种增强的精确形态在一定程度上有所不同。根据有关皮质胆碱能神经支配来源的最新知识对结果进行了讨论。

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引用本文的文献

1
Evidence for an increased rate of choline efflux across erythrocyte membranes in Alzheimer's disease.阿尔茨海默病中红细胞膜胆碱外流速率增加的证据。
Neurochem Res. 1985 Jul;10(7):909-18. doi: 10.1007/BF00964628.
2
Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease.阿尔茨海默病患者大脑中一种60000道尔顿蛋白质的体外磷酸化增加。
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9764-7. doi: 10.1073/pnas.83.24.9764.
3
Neocortical morphometry and cholinergic neurochemistry in Pick's disease.
皮克病中的新皮质形态测量学与胆碱能神经化学
Am J Pathol. 1988 Jun;131(3):507-18.