Yamada H, Oi S
No Shinkei Geka. 1985 Jul;13(7):749-54.
The authors report a 11-year-old girl with a huge intraspinal malignant teratoma associated with spinal arachnoid cyst. At seven year of age, suprasellar tumor was diagnosed and the patient received radiation therapy for tumor bed with total dose of 4,225 rads. As the result, marked decrease of the size of tumor was seen by follow-up CT scan. Serum alphafetoprotein (AFP) and human chorionic gonadotropin (HCG) level were at 51ng/ml and 31IU/l when total dose of 2,000 rads were over, and they decreased to 3ng/ml and 6.6IU/l at the dose of 4,225 rads respectively. The histology of the suprasellar tumor was unverified. She was discharged without any neurological deficits. For next 24 months, she received intrathecal administration of Methotrexate by repeated lumber puncture in 14 times. She remained intact neurologically. At eleven years of age, four years later, she started complaining of the right leg pain. On the examination, hypesthesia in the L distribution and stiff neck with positive straight leg raising test were observed. Urinary and bowel function were intact. CT scan of the head revealed residual of the suprasellar tumor but the size of the tumor was unchanged. Myelography showed complete block at the level of L. Laminectomy at L was performed and brownish cyst was found in the intradural space. Aspiration of cyst content and cyst wall resection were carried out. Histology of the cyst membrane was arachnoid and spinal arachnoid cyst was diagnosed. The postoperative course was uneventful until 13th postoperative day, when acute progressive paraparesis and numbness of bilateral toes were seen.(ABSTRACT TRUNCATED AT 250 WORDS)
作者报告了一名11岁女孩,患有巨大的脊髓内恶性畸胎瘤并伴有脊髓蛛网膜囊肿。7岁时,诊断出鞍上肿瘤,患者接受了肿瘤床放射治疗,总剂量为4225拉德。结果,随访CT扫描显示肿瘤大小明显减小。当总剂量达到2000拉德时,血清甲胎蛋白(AFP)和人绒毛膜促性腺激素(HCG)水平分别为51ng/ml和31IU/l,在剂量达到4225拉德时,它们分别降至3ng/ml和6.6IU/l。鞍上肿瘤的组织学未得到证实。她出院时没有任何神经功能缺损。在接下来的24个月里,她通过重复腰椎穿刺鞘内注射甲氨蝶呤14次。她的神经功能保持完好。4年后,11岁时,她开始抱怨右腿疼痛。检查时,发现L分布区感觉减退,直腿抬高试验阳性且颈部僵硬。泌尿和肠道功能正常。头部CT扫描显示鞍上肿瘤有残留,但肿瘤大小未变。脊髓造影显示L水平完全梗阻。在L行椎板切除术,在硬膜内空间发现褐色囊肿。进行了囊肿内容物抽吸和囊肿壁切除。囊肿膜的组织学检查为蛛网膜,诊断为脊髓蛛网膜囊肿。术后过程一直顺利,直到术后第13天,出现急性进行性双侧下肢轻瘫和双侧脚趾麻木。(摘要截短于250字)