Alka H Hande, Amol Gadbail, Archana Sonone, Swati K Patil, Aayushi Pakhale, Preethi N Sharma
Department and Institution, Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education & Research (Deemed to be University, Wardha, Maharashtra, 442001, India.
Department and Institution, Department of Dentistry, Government Medical College & Hospital, Nagpur, Maharashtra, India.
BMC Cancer. 2025 Jun 5;25(1):1000. doi: 10.1186/s12885-025-14415-2.
Oral squamous cell carcinoma (OSCC) associated with oral submucous fibrosis (OSMF) constitutes a clinicopathologically distinct entity in context to younger age of presentation, better histological grade of tumor differentiation, and lower risk of nodal metastasis. This study is intended to provide the basis of clinical presentation of OSCC associated with OSMF to consider a clinicopathologically unique entity compared to OSCC without OSMF.
The cohort of 320 OSCC patients was divided into two groups based on the association of OSMF. Group one, OSCC without OSMF (n = 166), whereas Group two, OSCC associated with OSMF (n = 154). The varied clinical presentation were categorized as, erythroplakic, erythro-leukoplakic, ulcerative/endophytic, ulcero-proliferative, and proliferative/exophytic. The variations in clinical presentation between the OSCC without OSMF and OSCC associated with OSMF groups were assessed using one-way ANOVA and the Tukey's HSD test.
Group one cohort presented with, significantly high number of cases clinically as ulcerative/endophytic 72 (43.4%) followed by ulcero-proliferative 53 (31.9%), erythro-leukoplakic 30 (18.1%), proliferative/exophytic 8 (4.8%) and erythroplakic 3 (1.8%). Whereas in Group two, significantly high number of cases clinically presented as nearly equal number of ulcero-proliferative 55 (35.7%) and proliferative/exophytic 50 (32.5%) followed by ulcerative/endophytic 25 (16.2%), erythro-leukoplakic 18 (11.7%) and erythroplakic 6 (3.9%) (p < 0.001).
Significantly high number of cases of OSCC associated with OSMF clinically presented as ulcero-proliferative and proliferative/exophytic. This characteristic clinical presentation may contribute in early detection and diagnosis by providing considerable period for recognition and treatment planning and thus better prognosis in OSCC associated with OSMF cases.
与口腔黏膜下纤维化（OSMF）相关的口腔鳞状细胞癌（OSCC）在发病年龄较轻、肿瘤分化组织学分级较好以及淋巴结转移风险较低方面构成一种临床病理上独特的实体。本研究旨在提供与OSMF相关的OSCC的临床表现依据，以便将其视为与无OSMF的OSCC相比在临床病理上独特的实体。
320例OSCC患者队列根据是否存在OSMF分为两组。第一组，无OSMF的OSCC（n = 166），而第二组，与OSMF相关的OSCC（n = 154）。将不同的临床表现分类为红斑型、红白斑型、溃疡型/内生型、溃疡增殖型和增殖型/外生型。使用单因素方差分析和Tukey's HSD检验评估无OSMF的OSCC组和与OSMF相关的OSCC组之间临床表现的差异。
第一组队列临床上溃疡型/内生型病例数显著较多，为72例（43.4%），其次是溃疡增殖型53例（31.9%）、红白斑型30例（18.1%）、增殖型/外生型8例（4.8%）和红斑型3例（1.8%）。而在第二组中，临床上溃疡增殖型55例（35.7%）和增殖型/外生型50例（32.5%）的病例数几乎相等，显著较多，其次是溃疡型/内生型25例（16.2%）、红白斑型18例（11.7%）和红斑型6例（3.9%）（p < 0.001）。
与OSMF相关的OSCC病例临床上溃疡增殖型和增殖型/外生型的病例数显著较多。这种特征性的临床表现可能通过提供相当长的识别和治疗计划时间有助于早期发现和诊断，从而使与OSMF相关的OSCC病例获得更好的预后。
