Lin Lihui, Lin Yansong, Ling Xin, Zhang Zewen, Guo Xianwen, Ding Zhen
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China.
Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
Nutr Metab (Lond). 2025 Jun 5;22(1):55. doi: 10.1186/s12986-025-00956-7.
Investigating the risk of acute pancreatitis (AP) recurrence is crucial because it affects public health and medical resources. The triglyceride-glucose index (TyG-i) is recognized as a reliable marker of insulin resistance (IR), which occurs after an AP attack. However, the predictive value of the TyG-i during the first AP for subsequent recurrence remains unclear.
Patients with their first AP episode between January 2014 and December 2023 were followed up retrospectively. Data on demographic characteristics, imaging findings, and laboratory examinations of their first episode and recurrences were collected. The TyG-i was calculated as follows: ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Factors associated with AP were evaluated using Cox regression analyses.
A total of 853 patients were enrolled in our study, 180 (21.1%) of whom experienced a recurrence after the first AP episode. The recurrence rate was higher in the high TyG-i index group (n = 111, 26.0%) than in the low TyG-i index group (n = 69, 16.2%; P < 0.001). Cox regression analyses revealed TyG-i as an independent predictor of AP recurrence in all etiologies (hazard ratio [HR] = 1.535, P = 0.007), as well as for the recurrence of acute biliary pancreatitis (HR = 1.829, P = 0.035).
TyG-i status at the first AP episode could independently predict recurrence.
研究急性胰腺炎（AP）复发风险至关重要，因为它会影响公共卫生和医疗资源。甘油三酯-葡萄糖指数（TyG-i）被认为是胰岛素抵抗（IR）的可靠标志物，胰岛素抵抗在AP发作后出现。然而，首次AP发作时TyG-i对后续复发的预测价值仍不明确。
对2014年1月至2023年12月期间首次发生AP的患者进行回顾性随访。收集其首次发作和复发时的人口统计学特征、影像学检查结果及实验室检查数据。TyG-i的计算方法如下：ln[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]。采用Cox回归分析评估与AP相关的因素。
本研究共纳入853例患者，其中180例（占21.1%）在首次AP发作后复发。高TyG-i指数组（n = 111，占26.0%）的复发率高于低TyG-i指数组（n = 69，占16.2%；P < 0.001）。Cox回归分析显示，TyG-i是所有病因AP复发的独立预测因子（风险比[HR] = 1.535，P = 0.007），也是急性胆源性胰腺炎复发的独立预测因子（HR = 1.829，P = 0.035）。
首次AP发作时的TyG-i状态可独立预测复发。
