Department of Internal Medicine, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Division of Gastroenterology and Hepatology, Hallym University College of Medicine, Chuncheon, Republic of Korea.
Pancreatology. 2020 Dec;20(8):1587-1591. doi: 10.1016/j.pan.2020.09.018. Epub 2020 Sep 28.
Early diagnosis of severe acute pancreatitis (AP) is important to reduce morbidity and mortality. We investigated the association between the triglyceride and glucose index (TyG index) and the prognosis of severe AP (SAP).
The TyG index was calculated as: ln [fasting triglycerides (mg/dL) x fasting plasma glucose (mg/dL)]/2. Multivariable logistic regression analyses were used to investigate the independent association between the TyG index and the severity of AP.
In this study, 373 patients with AP were recruited from three hospitals. The TyG index was higher in the SAP group than in the non-SAP group. Further, the TyG index was higher than in patients admitted to an intensive care unit and those who died of AP. The TyG index was an independent predictive factor for SAP (odds ratio 7.14, 95% confidence interval 2.80-18.19). The area under the curve increased significantly, from 0.738 to 0.830, after adding the TyG index to a predictive SAP model.
Our findings suggest that the TyG index is an independent prognostic factor in patients with AP and could be used as a simple prognostic indicator for SAP.
早期诊断重症急性胰腺炎（AP）对于降低发病率和死亡率至关重要。我们研究了甘油三酯和血糖指数（TyG 指数）与重症 AP（SAP）预后之间的关系。
TyG 指数的计算方法为：ln[空腹甘油三酯（mg/dL）x 空腹血糖（mg/dL）]/2。采用多变量 logistic 回归分析来研究 TyG 指数与 AP 严重程度之间的独立相关性。
本研究共纳入来自 3 家医院的 373 例 AP 患者。SAP 组的 TyG 指数高于非 SAP 组。此外，TyG 指数高于入住重症监护病房和因 AP 死亡的患者。TyG 指数是 SAP 的独立预测因素（比值比 7.14，95%置信区间 2.80-18.19）。在将 TyG 指数添加到预测 SAP 的模型后，曲线下面积从 0.738 显著增加到 0.830。
我们的研究结果表明，TyG 指数是 AP 患者的独立预后因素，可作为 SAP 的简单预后指标。
