Doghish Ahmed S, Abd-Elmawla Mai A, Aborehab Nora M, Radwan Abdullah F, Ghaiad Heba R, Nassar Khloud, Mohammed Osama A, Elimam Hanan
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Cairo, Egypt.
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
J Gene Med. 2025 Jun;27(6):e70026. doi: 10.1002/jgm.70026.
Renal cell carcinoma (RCC) is a malignant neoplasm arising from the renal epithelium and constitutes approximately 2% of global cancer diagnoses and mortalities. With increasing prevalence, RCC remains a pressing clinical challenge, particularly because of its resistance to conventional therapies and poor outcomes in advanced stages. Long noncoding RNAs (lncRNAs) have been proposed as key molecular mediators in RCC, orchestrating critical pathways such as epithelial-to-mesenchymal transition (EMT), cellular proliferation, apoptosis, angiogenesis, and metastasis. Their roles in therapeutic resistance, including chemoresistance and radioresistance, further highlight their impact on treatment outcomes. Additionally, the potential of natural compounds such as curcumin, quercetin, and resveratrol to target lncRNA-mediated pathways has garnered attention, offering insights into novel therapeutic strategies. This review examines the biogenic pathways and multifaceted functions of lncRNAs, shedding light on their influence on RCC pathophysiology and posttranscriptional regulation. In addition, this review emphasizes the repercussions of natural compounds as lncRNA-targeted therapies, thus offering a comprehensive perspective on emerging strategies that may lead to more effective and personalized treatments.
肾细胞癌（RCC）是一种起源于肾上皮的恶性肿瘤，约占全球癌症诊断和死亡病例的2%。随着发病率的上升，RCC仍然是一个紧迫的临床挑战，特别是由于其对传统疗法的耐药性以及晚期预后不佳。长链非编码RNA（lncRNAs）被认为是RCC中的关键分子介质，协调上皮-间质转化（EMT）、细胞增殖、凋亡、血管生成和转移等关键途径。它们在治疗耐药性（包括化学耐药性和放射耐药性）中的作用，进一步凸显了它们对治疗结果的影响。此外，姜黄素、槲皮素和白藜芦醇等天然化合物靶向lncRNA介导途径的潜力已引起关注，为新的治疗策略提供了思路。本综述探讨了lncRNAs的生物合成途径和多方面功能，揭示了它们对RCC病理生理学和转录后调控的影响。此外，本综述强调了天然化合物作为lncRNA靶向疗法的影响，从而为可能导致更有效和个性化治疗的新兴策略提供了全面的视角。
