Rost A, Rühl U, Brosig W
Urologe A. 1977 Mar;16(2):83-7.
The most frequent and most unpleasant side-effect of therapy with estrogen hormones in patients with carcinoma of the prostate is the painful gynecomastia. Since 1969, we have been performing the prophylactic irradiation of the mammary glands on 284 patients in order to prevent a hormone-induced gynecomastia. The majority (262 patients) was irradiated with 600 rad surface dose in fractions of 150 rad prior to the hormone therapy. One hundred and two patients, having been treated endocrinologically for 2-75 months, had a follow-up examination. After irradiation, only 19% of the patients did not develop a gynecomastia, and 60% had no mamillary hyperesthesias. Compared to other authors, the therapy was less efficient, the symptoms, however, were discrete. As a consequence, an increase of the radiation dose as well as an alteration of the fractionation must be used.
前列腺癌患者接受雌激素激素治疗时，最常见且最令人不适的副作用是疼痛性男子乳腺增生。自1969年以来，我们对284例患者进行了乳腺预防性照射，以预防激素诱导的男子乳腺增生。大多数患者（262例）在激素治疗前接受了表面剂量600拉德的照射，每次照射150拉德。102例接受内分泌治疗2至75个月的患者进行了随访检查。照射后，只有19%的患者未发生男子乳腺增生，60%的患者没有乳头感觉过敏。与其他作者相比，该治疗效果较差，但症状较轻。因此，必须增加辐射剂量并改变分次照射方案。
