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[对前列腺癌患者雌激素诱导的男性乳腺增生进行乳腺腺体照射作为预防性治疗(作者译)]

[Irradiation of the breast glands as prophylactic treatment of an estrogen-induced gynecomastia in patients with prostate carcinomas (author's transl)].

作者信息

Metzger H, Junker A, Voss A C

出版信息

Strahlentherapie. 1980 Feb;156(2):102-4.

PMID:7355408
Abstract

One hundred and four patients with histologically demonstrated prostate carcinomas were submitted to a bilateral orchiectomy. Before the beginning of a hormone therapy, both breast glands were irradiated prophylactically. The patients were observed between two and thirty months. The radiotherapy was executed with electrons with an energy of 10 to 12 MeV and by a stationary field which had a size of 10 X 10 cm. A total surface dose of 12,0 Gy was applicated in four single doses of 3,0 Gy each. The symptom-less healing of 45% of the pateints and the rate of only 29% of patients with gynecomastia is considered to be a good result. In view of the success achieved by the hormone therapy, subjective complaints such as hyperesthesia, pains and pruritus are regarded to be less important.

摘要

104例经组织学证实为前列腺癌的患者接受了双侧睾丸切除术。在开始激素治疗前,对双侧乳腺进行了预防性照射。对患者进行了2至30个月的观察。放疗采用能量为10至12兆电子伏的电子线,通过一个大小为10×10厘米的固定野进行。总表面剂量为12.0戈瑞,分4次给予,每次3.0戈瑞。45%的患者无症状愈合,男性乳房发育患者的发生率仅为29%,这被认为是一个良好的结果。鉴于激素治疗取得的成功,诸如感觉过敏、疼痛和瘙痒等主观症状被认为不太重要。

相似文献

1
[Irradiation of the breast glands as prophylactic treatment of an estrogen-induced gynecomastia in patients with prostate carcinomas (author's transl)].[对前列腺癌患者雌激素诱导的男性乳腺增生进行乳腺腺体照射作为预防性治疗(作者译)]
Strahlentherapie. 1980 Feb;156(2):102-4.
2
[Irradiation for prevention of gynecomastia prior to estrogen therapy in cases of carcinoma of the prostate (author's transl)].前列腺癌病例中雌激素治疗前预防男性乳房发育的放射治疗(作者译)
Urologe A. 1977 Mar;16(2):83-7.
3
[Alternative contrasexual hormone treatment following fibrosing breast irradiation in prostatic carcinoma. Retrospective analysis of 123 patients].[前列腺癌纤维化乳腺放疗后的替代性异性激素治疗。123例患者的回顾性分析]
Strahlentherapie. 1983 Aug;159(8):465-9.
4
[Breast irradiation preceding hormone administration in patients with prostatic carcinoma].[前列腺癌患者激素给药前的乳房照射]
Strahlentherapie. 1974 Jul;148(1):35-8.
5
[Gynecomastia as a complication of hormonotherapy for prostate cancer: effect of prophylactic breast irradiation].[男性乳腺增生作为前列腺癌激素治疗的并发症:预防性乳腺照射的效果]
Harefuah. 2007 Feb;146(2):126-8, 164-5.
6
Prophylactic breast irradiation with a single dose of electron beam radiotherapy (10 Gy) significantly reduces the incidence of bicalutamide-induced gynecomastia.单次剂量电子束放射治疗(10 Gy)进行预防性乳腺照射可显著降低比卡鲁胺所致男性乳房发育症的发生率。
Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):476-83. doi: 10.1016/j.ijrobp.2004.03.022.
7
Gynecomastia and breast pain induced by adjuvant therapy with bicalutamide after radical prostatectomy in patients with prostate cancer: the role of tamoxifen and radiotherapy.前列腺癌患者根治性前列腺切除术后比卡鲁胺辅助治疗引起的男性乳腺增生和乳腺疼痛:他莫昔芬和放疗的作用
J Urol. 2005 Dec;174(6):2197-203. doi: 10.1097/01.ju.0000181824.28382.5c.
8
Is prophylactic breast radiotherapy necessary in all patients with prostate cancer and gynecomastia and/or breast pain?对于所有患有前列腺癌和男性乳房发育症和/或乳房疼痛的患者,预防性乳房放疗是否有必要?
J Urol. 2010 Aug;184(2):519-24. doi: 10.1016/j.juro.2010.03.137. Epub 2010 Jun 17.
9
[X-ray prevention of gynecomastia in prostatic carcinoma patients during estrogen therapy].[雌激素治疗期间前列腺癌患者男性乳房发育症的X线预防]
Duodecim. 1967;83(22):1280-4.
10
Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs?对于接受雄激素抑制药物治疗的前列腺癌患者,预防性乳腺照射会导致心脏毒性吗?
Radiat Oncol. 2008 Jan 10;3:2. doi: 10.1186/1748-717X-3-2.

引用本文的文献

1
Radiotherapy for prevention and therapy of gynecomastia due to antiandrogen treatment in prostate cancer patients: a patterns-of-care study.放射治疗预防和治疗前列腺癌患者抗雄激素治疗引起的男性乳房发育症:一项治疗模式研究。
Strahlenther Onkol. 2011 Dec;187(12):771-7. doi: 10.1007/s00066-011-2283-x. Epub 2011 Nov 29.