Liu Yang, Zhou Luting, Yang Xianwei, Xie Jing, Yuan Fei, Xu Haimin, Wang Chaofu, Yang Xiaoqun
Department of Pathology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.
Pathologica. 2025 Apr;117(2):162-164. doi: 10.32074/1591-951X-1122.
Eosinophilic vacuolated tumor (EVT) is an emerging renal entity and further studies are required to characterize this neoplasm. EVT is considered generally indolent because metastasis or death from the disease has never been reported. Herein, we report the first case of EVT with mediastinal lymph node metastasis to validate its at least borderline behavior. Based on the morphological features, we additionally used a large panel of immunohistochemical antibodies and next-generation sequencing (NGS) to confirm the diagnosis of EVT and exclude other renal entities. This case report highlights the notion that EVT can exhibit mediastinal lymph node metastasis and patients with EVT need to be closely followed.
嗜酸性空泡状肿瘤（EVT）是一种新出现的肾脏病变，需要进一步研究以明确该肿瘤的特征。EVT通常被认为生长缓慢，因为从未有过该疾病转移或导致死亡的报道。在此，我们报告首例发生纵隔淋巴结转移的EVT病例，以证实其至少具有临界恶性行为。基于形态学特征，我们还使用了大量免疫组化抗体和二代测序（NGS）来确诊EVT并排除其他肾脏病变。本病例报告强调了EVT可出现纵隔淋巴结转移这一观点，EVT患者需要密切随访。
