Sakko Samuli, Tulppo Mikko P, Koivunen Peppi, Tapio Joona
Research Unit of Extracellular Matrix and Hypoxia, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Research Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Physiol Rep. 2025 Jun;13(11):e70406. doi: 10.14814/phy2.70406.
High hemoglobin (Hb) levels within normal variation range are considered beneficial. However, lower Hb levels within normal variation range are associated with healthier cardiovascular traits. Heart rate variability (HRV) and baroreflex sensitivity (BRS) are dysregulated in cardiovascular diseases (CVDs). We have shown in a hypertensive cohort that higher Hb levels are associated with impaired HRV and BRS. As CVDs are exacerbated by aging, conditions like hypertension and factors such as smoking, further studies on the association of Hb levels and HRV and BRS on younger and healthier populations are required for the generalization of these associations. The aims were to cross-sectionally study the association of Hb levels with HRV and BRS in the Northern Finland Birth Cohort 1966 (NFBC1966) at 46 years (n = 5342) and to evaluate confounding factors, such as smoking, on these associations. Higher Hb levels within normal variation range were associated with adverse time-domain measures, including elevated heart rate (HR). Hb levels were negatively associated with high-frequency (HF) power and positively with the low frequency (LF) to HF ratio (LF/HF). These associations were influenced by sex, metabolic parameters, and smoking but were observed regardless of these factors. For BRS, adjusting for metabolic covariates nullified the association with Hb levels.
在正常变化范围内，较高的血红蛋白（Hb）水平被认为是有益的。然而，在正常变化范围内较低的Hb水平与更健康的心血管特征相关。心血管疾病（CVD）患者的心率变异性（HRV）和压力反射敏感性（BRS）失调。我们在一个高血压队列中发现，较高的Hb水平与HRV和BRS受损有关。由于CVD会随着年龄增长而加剧，像高血压这样的病症以及吸烟等因素，因此需要对更年轻、更健康人群中Hb水平与HRV和BRS之间的关联进行进一步研究，以便推广这些关联。目的是对1966年芬兰北部出生队列（NFBC1966）中46岁（n = 5342）人群的Hb水平与HRV和BRS之间的关联进行横断面研究，并评估吸烟等混杂因素对这些关联的影响。在正常变化范围内较高的Hb水平与不良的时域指标相关，包括心率（HR）升高。Hb水平与高频（HF）功率呈负相关，与低频（LF）与高频比值（LF/HF）呈正相关。这些关联受性别、代谢参数和吸烟的影响，但无论这些因素如何都能观察到。对于BRS，调整代谢协变量后消除了与Hb水平的关联。
