纯合子布拉特洛维大鼠的局部脑葡萄糖利用情况。

Local cerebral glucose utilization in the homozygous Brattleboro rat.

作者信息

Schwartz W J, Crosby G

出版信息

Neurosci Lett. 1985 Jul 31;58(2):171-6. doi: 10.1016/0304-3940(85)90159-4.

Abstract

The [14C]deoxyglucose technique was used to measure brain glucose utilization in homozygous male Brattleboro and age-matched Long-Evans control rats. Brattleboro homozygotes had significantly higher daily water intakes and plasma osmolalities and significantly lower body weights than controls. Glucose utilization for the brain as a whole and for 46 discrete brain structures was not significantly different for the two strains. Our results indicate that vasopressin is not essential for the maintenance of overall brain glucose utilization in resting, awake rats.

摘要

采用[14C]脱氧葡萄糖技术测定纯合雄性布拉德福德大鼠和年龄匹配的长 Evans 对照大鼠的脑葡萄糖利用率。与对照组相比，布拉德福德纯合子的每日饮水量和血浆渗透压显著更高，体重显著更低。两种品系大鼠的全脑以及 46 个离散脑区的葡萄糖利用率并无显著差异。我们的结果表明，对于静息、清醒的大鼠，血管加压素并非维持全脑葡萄糖利用所必需。