Peschanski M, Briand A, Poingt J P, Guilbaud G
Neurosci Lett. 1985 Aug 5;58(3):287-92. doi: 10.1016/0304-3940(85)90068-0.
Kainic acid (KA) has been largely used as a neurotoxin, and its axon-sparing effect being repeatedly emphasized, on the basis of anatomical and biochemical data. The present study examines this 'axon-sparing' effect from an electrophysiological point of view and demonstrates that lemniscal fibers retain the capacity to convey somesthetic information 5-60 days after an injection of KA in the ventrobasal complex of the thalamus depriving these afferent fibers of their target cells.
海藻酸（KA）在很大程度上被用作一种神经毒素，基于解剖学和生物化学数据，其轴突保留效应被反复强调。本研究从电生理学角度研究了这种“轴突保留”效应，并证明在丘脑腹侧基底复合体注射KA使这些传入纤维的靶细胞缺失后，lemniscal纤维在5 - 60天内仍保留传递躯体感觉信息的能力。
