原发性先天性青光眼小梁网的组织病理学变化
Histopathological changes in the trabecular meshwork in primary congenital glaucoma.
作者信息
Rao Aparna
机构信息
Glaucoma Service, LV Prasad Eye Institute, MTC campus and KALLAM ANJI REDDY campus, Hyderabad, 500018, India.
出版信息
Am J Ophthalmol Case Rep. 2025 Apr 16;38:102340. doi: 10.1016/j.ajoc.2025.102340. eCollection 2025 Jun.
PURPOSE
To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma.
METHODS
Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients with primary congenital glaucoma (mean age) were analyzed using and eosin staining.
RESULTS
The trabecular meshwork in PCG showed an expansion of the juxtacanalicular and corneoscleral meshwork regions with increased cellularity, thickened TM beams, prominent spindle-shaped nuclei suggesting epithelial mesenchymal transformation predominantly and two morphologically distinct zones of the juxtacanalicular region.
CONCLUSIONS
Increased cellularity, zonal expansion and mesenchymal changes in specific TM regions suggest aberrant differentiation and differential dysgenesis of different TM regions in PCG.
目的
评估原发性先天性青光眼患者离体小梁网（TM）标本的形态学变化。
方法
对4例原发性先天性青光眼患者（平均年龄）在微切口小梁切除术后获得的5个小梁网（TM）标本进行苏木精和伊红染色分析。
结果
原发性先天性青光眼患者的小梁网显示近管区和角膜巩膜网区域扩张，细胞增多，TM束增厚，梭形核突出，主要提示上皮-间质转化，且近管区有两个形态学上不同的区域。
结论
特定TM区域的细胞增多、区域扩张和间质变化提示原发性先天性青光眼不同TM区域存在异常分化和差异性发育异常。
Zotero 插件