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一例成功使用司库奇尤单抗联合小剂量甲氨蝶呤治疗以确保持续清除的红皮病型银屑病病例报告

A Case of Erythrodermic Psoriasis Successfully Treated With Ixekizumab Combined With Low-Dose Methotrexate to Ensure Sustained Clearance: A Case Report.

作者信息

Ngo Jennifer Lavina, Tumalad Lily Lyralin, Tinio Patricia Anne, Balagat Rogelio

机构信息

Department of Dermatology, Rizal Medical Center, Pasig, Philippines.

出版信息

Case Rep Dermatol Med. 2025 May 29;2025:8810497. doi: 10.1155/crdm/8810497. eCollection 2025.

DOI:10.1155/crdm/8810497
PMID:40475334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12140818/
Abstract

Erythrodermic psoriasis (EP) is a severe type of psoriasis that requires immediate and effective treatment to prevent serious complications. Although recommended as first-line treatment for EP, conventional systemic disease-modifying antirheumatic drugs (csDMARDs) such as methotrexate and/or cyclosporine can sometimes be ineffective or undesirable, hence the use of biologics. However, in cases of refractory disease, biologics may be combined with methotrexate to boost efficacy and optimize outcomes without compromising safety and tolerability.

摘要

红皮病型银屑病（EP）是一种严重的银屑病类型，需要立即进行有效治疗以预防严重并发症。尽管甲氨蝶呤和/或环孢素等传统全身性改善病情抗风湿药（csDMARDs）被推荐作为EP的一线治疗药物，但有时可能无效或不理想，因此会使用生物制剂。然而，在难治性疾病的情况下，生物制剂可与甲氨蝶呤联合使用，以提高疗效并优化治疗结果，同时不影响安全性和耐受性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e8/12140818/fc28508baeb5/CRIDM2025-8810497.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e8/12140818/fc28508baeb5/CRIDM2025-8810497.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e8/12140818/fc28508baeb5/CRIDM2025-8810497.001.jpg

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本文引用的文献

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Pediatric Health Med Ther. 2023 Nov 14;14:435-451. doi: 10.2147/PHMT.S389108. eCollection 2023.
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Demography, baseline disease characteristics and treatment history of patients with psoriasis in the Philippines: A multicenter, retrospective study.
Australas J Dermatol. 2023 May;64(2):e178-e182. doi: 10.1111/ajd.14021. Epub 2023 Mar 13.
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Economic Evaluation of Selected Interleukin Inhibitors Versus Methotrexate for Moderate-to-Severe Plaque Psoriasis From the Philippine Payer Perspective.从菲律宾医保支付方角度评估特定白细胞介素抑制剂与甲氨蝶呤治疗中重度斑块状银屑病的经济学效果
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4
Efficacy and safety of ixekizumab in patients with active psoriatic arthritis with and without concomitant conventional disease-modifying antirheumatic drugs: SPIRIT-P1 and SPIRIT-P2 3-year results.依奇珠单抗治疗活动性银屑病关节炎患者的疗效和安全性：SPIRIT-P1 和 SPIRIT-P2 研究 3 年结果。有和无合并使用传统疾病修正抗风湿药物。
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Updates on the Treatment of Erythrodermic Psoriasis.红皮病型银屑病治疗的最新进展
Psoriasis (Auckl). 2021 Jun 9;11:59-73. doi: 10.2147/PTT.S288345. eCollection 2021.
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Dermatol Ther. 2021 May;34(3):e14926. doi: 10.1111/dth.14926. Epub 2021 Mar 16.
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Two cases of refractory erythrodermic psoriasis effectively treated with secukinumab and a review of the literature.两例难治性红皮病型银屑病患者经司库奇尤单抗治疗有效，并进行文献复习。
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