Conceição Dos Santos Thiago, Tavares Dos Santos Rildo, Oliveira Hudson Renatode Paula, Angeli Felipe Mendes Barcelos, Bispo Emanuelly Augustada Silva, Bahiense Ian Manhoni, Filho Walter Gomesda Silva, Areas Guilherme Peixoto Tinoco, Arêas Fernando Zanelada Silva
Neurorehabilitation and Neuromodulation Laboratory, Department of Physiological Sciences, Federal University of Espírito Santo, City of Vitória, ES, Brazil.
Physical Education and Sports Center, Federal University of Espírito Santo, Espírito Santo, Brasil.
MethodsX. 2025 Apr 25;14:103335. doi: 10.1016/j.mex.2025.103335. eCollection 2025 Jun.
This study will investigate the effects of high-frequency Transcranial Magnetic Stimulation (TMS) on lower limb muscle strength, using an isokinetic dynamometer to measure strength changes. The research will involve 50 healthy sedentary male participants aged 18-25, randomized into active and sham groups. The protocol will integrate TMS with surface electromyography (sEMG) to assess muscle activation and enhance accuracy. The aim will be to explore whether TMS can influence peripheral neuromuscular characteristics, improving muscle performance. The protocol will involve a double-blind, randomized design and the use of an isokinetic dynamometer for precise muscle strength measurement. By employing TMS, which enhances cortical excitability, and evaluating muscle performance via controlled assessments, the study will seek to provide reliable pre- and post-intervention data. The study's sample calculation will ensure adequate statistical power and account for potential attrition, with 50 participants included. This research will have potential clinical applications, particularly for muscle rehabilitation and performance optimization. However, it will face limitations, such as a male-only sample and variability in individual responses to TMS. Despite these challenges, the study's findings could inform future therapeutic strategies for enhancing muscle strength and contribute to advancing TMS applications in both clinical and athletic settings.
本研究将使用等速测力计测量力量变化，以探究高频经颅磁刺激（TMS）对下肢肌肉力量的影响。该研究将纳入50名年龄在18至25岁之间、久坐不动的健康男性参与者，随机分为实验组和假刺激组。研究方案将TMS与表面肌电图（sEMG）相结合，以评估肌肉激活情况并提高准确性。其目的是探索TMS是否能够影响外周神经肌肉特征，改善肌肉表现。该方案将采用双盲随机设计，并使用等速测力计进行精确的肌肉力量测量。通过运用增强皮质兴奋性的TMS，并通过对照评估来评估肌肉表现，该研究将力求提供可靠的干预前后数据。该研究的样本计算将确保足够的统计效力，并考虑到潜在的损耗，共纳入50名参与者。这项研究将具有潜在的临床应用价值，特别是在肌肉康复和性能优化方面。然而，它也将面临一些限制，比如仅以男性为样本以及个体对TMS反应的变异性。尽管存在这些挑战，但该研究的结果可能为未来增强肌肉力量的治疗策略提供参考，并有助于推动TMS在临床和运动领域的应用。
