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对于既往合并乙型肝炎病毒（HBV）感染的艾滋病毒感染者，是否应改用长效注射用卡博特韦/利匹韦林：哪些HBV标志物可用于管理HBV再激活风险？

To Switch or not to Switch to Long-acting Injectable Cabotegravir/Rilpivirine in PWH With Past Hepatitis B Virus (HBV) Coinfection: Which HBV Markers to Manage Risk of HBV Reactivation?

作者信息

Ollier Laurence, De Monte Anne, Thibault Vincent, Pugliese Pascal, Chirio David, Durant Jacques, Carles Michel, Naqvi Alissa

机构信息

Virology Laboratory, Biological and pathological Center, Nice University Hospital, Nice, France.

Virology Laboratory, Rennes University Hospital, Rennes, France.

出版信息

Open Forum Infect Dis. 2025 May 6;12(6):ofaf266. doi: 10.1093/ofid/ofaf266. eCollection 2025 Jun.

DOI:10.1093/ofid/ofaf266
PMID:40476032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12138246/
Abstract

We report the occurrence of low-level hepatitis B virus (HBV) viremia in people with HIV with controlled CD4 counts and isolated core antibody reactivity switched to long-acting injectable cabotegravir/rilpivirine. This series raises questions about the reintroduction of anti-HBV medications, presents the variation of several HBV markers alongside HBV-DNA and reveals an effective spontaneous immune response.

摘要

我们报告了在接受长效注射卡博特韦/利匹韦林治疗、CD4计数得到控制且仅核心抗体反应呈阳性的HIV感染者中出现低水平乙型肝炎病毒（HBV）血症的情况。该系列病例引发了关于重新启用抗HBV药物的问题，呈现了几种HBV标志物与HBV-DNA的变化情况，并揭示了一种有效的自发免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/12138246/dd1b37cdea48/ofaf266f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/12138246/dd1b37cdea48/ofaf266f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/12138246/dd1b37cdea48/ofaf266f1.jpg

相似文献

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To Switch or not to Switch to Long-acting Injectable Cabotegravir/Rilpivirine in PWH With Past Hepatitis B Virus (HBV) Coinfection: Which HBV Markers to Manage Risk of HBV Reactivation?对于既往合并乙型肝炎病毒（HBV）感染的艾滋病毒感染者，是否应改用长效注射用卡博特韦/利匹韦林：哪些HBV标志物可用于管理HBV再激活风险？
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本文引用的文献

1
Hepatitis B Virus Reactivation after Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody.拉替拉韦/恩曲他滨/替诺福韦酯治疗后低乙肝表面抗体患者换用卡替拉韦/利匹韦林后乙型肝炎病毒再激活
Emerg Infect Dis. 2024 Aug;30(8):1668-1671. doi: 10.3201/eid3008.240019.
2
Immune Reconstitution Inflammatory Syndrome in Aids Patient After Successful Induction of Virological Suppression with Cabotegravir/Rilpivirine.使用卡博特韦/利匹韦林成功诱导病毒学抑制后艾滋病患者的免疫重建炎症综合征
Eur J Case Rep Intern Med. 2023 Jul 13;10(8):003981. doi: 10.12890/2023_003981. eCollection 2023.
3
Brief Report: Hepatitis B Infection or Reactivation After Switch to 2-Drug Antiretroviral Therapy: A Case Series, Literature Review, and Management Discussion.
简报：转换为二联抗反转录病毒治疗后乙型肝炎感染或再激活：病例系列、文献复习和管理讨论。
J Acquir Immune Defic Syndr. 2023 Oct 1;94(2):160-164. doi: 10.1097/QAI.0000000000003239.
4
Hepatitis B Core Antibody Level: A Surrogate Marker for Host Antiviral Immunity in Chronic Hepatitis B Virus Infections.乙型肝炎核心抗体水平：慢性乙型肝炎病毒感染中宿主抗病毒免疫的替代标志物。
Viruses. 2023 May 3;15(5):1111. doi: 10.3390/v15051111.
5
Hepatitis B reactivation after tenofovir withdrawal in an HIV-infected patient with history of cured hepatitis B virus infection and poor immunological status.一名曾治愈乙肝病毒感染且免疫状态不佳的HIV感染患者停用替诺福韦后发生乙肝再激活。
AIDS. 2021 Aug 1;35(10):1707-1708. doi: 10.1097/QAD.0000000000002941.
6
Long-Acting Cabotegravir and Rilpivirine for Maintenance of HIV-1 Suppression.长效卡替拉韦和利匹韦林维持治疗 HIV-1 抑制。
N Engl J Med. 2020 Mar 19;382(12):1112-1123. doi: 10.1056/NEJMoa1904398. Epub 2020 Mar 4.
7
Non-invasive biomarkers for chronic hepatitis B virus infection management.慢性乙型肝炎病毒感染管理的无创生物标志物。
Antiviral Res. 2019 Sep;169:104553. doi: 10.1016/j.antiviral.2019.104553. Epub 2019 Jul 6.
8
HIV-hepatitis B virus coinfection: epidemiology, pathogenesis, and treatment.HIV-乙型肝炎病毒合并感染：流行病学、发病机制和治疗。
AIDS. 2017 Sep 24;31(15):2035-2052. doi: 10.1097/QAD.0000000000001574.
9
Adjustment of antiretroviral regimen may lead to HBV reactivation even in patients with past HBV infection serological profile.调整抗逆转录病毒治疗方案可能导致 HBV 再激活，即使在过去 HBV 感染血清学特征的患者中也是如此。
J Infect Chemother. 2013 Oct;19(5):987-9. doi: 10.1007/s10156-013-0560-6. Epub 2013 Feb 5.
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Reactivation of hepatitis B.乙型肝炎再激活
Hepatology. 2009 May;49(5 Suppl):S156-65. doi: 10.1002/hep.22945.