拉替拉韦/恩曲他滨/替诺福韦酯治疗后低乙肝表面抗体患者换用卡替拉韦/利匹韦林后乙型肝炎病毒再激活
Hepatitis B Virus Reactivation after Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody.
出版信息
Emerg Infect Dis. 2024 Aug;30(8):1668-1671. doi: 10.3201/eid3008.240019.
Abstract
A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine/tenofovir alafenamide to cabotegravir/rilpivirine. An immune escape mutation, E164V, was identified in the isolated HBV DNA.
摘要
一名日本的 HIV 患者 15 年前因急性乙型肝炎病毒 (HBV) 而开始接受抗逆转录病毒治疗，其乙型肝炎表面抗体水平较低，在从比克替拉韦/恩曲他滨/替诺福韦艾拉酚胺转换为卡替拉韦/利匹韦林后 4 个月发生了 HBV 突破再激活。在分离的 HBV DNA 中鉴定出了一个免疫逃逸突变 E164V。
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