Emerg Infect Dis. 2024 Aug;30(8):1668-1671. doi: 10.3201/eid3008.240019.
A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine/tenofovir alafenamide to cabotegravir/rilpivirine. An immune escape mutation, E164V, was identified in the isolated HBV DNA.
一名日本的 HIV 患者 15 年前因急性乙型肝炎病毒 (HBV) 而开始接受抗逆转录病毒治疗,其乙型肝炎表面抗体水平较低,在从比克替拉韦/恩曲他滨/替诺福韦艾拉酚胺转换为卡替拉韦/利匹韦林后 4 个月发生了 HBV 突破再激活。在分离的 HBV DNA 中鉴定出了一个免疫逃逸突变 E164V。