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疫苗激发试验后重新分类的疫苗诱导过敏反应病例报告。

Case report of vaccine-induced anaphylactic reaction reclassified after vaccine challenge.

作者信息

Aman Maria, Abou Turk Chirine A, Carlson John C

机构信息

Ochsner Health System, New Orleans, La.

出版信息

J Allergy Clin Immunol Glob. 2025 Apr 22;4(3):100484. doi: 10.1016/j.jacig.2025.100484. eCollection 2025 Aug.

Abstract

At age 4 months, an infant had skin changes and cessation of breathing responsive to epinephrine after vaccine administration. The atypical breathing recurred during vaccine challenge but was consistent with breath-holding spell rather than anaphylaxis. Vaccine challenges can be performed in appropriate settings even when cases are consistent with anaphylaxis.

摘要

4个月大的婴儿在接种疫苗后出现皮肤变化,且呼吸停止,肾上腺素治疗有效。在疫苗激发试验期间,非典型呼吸再次出现,但符合屏气发作而非过敏反应。即使病例符合过敏反应,也可在适当环境下进行疫苗激发试验。

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本文引用的文献

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Anaphylaxis: Revision of the Brighton collaboration case definition.过敏反应:布莱顿合作研究修订的病例定义。
Vaccine. 2023 Apr 6;41(15):2605-2614. doi: 10.1016/j.vaccine.2022.11.027. Epub 2022 Nov 24.
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Vaccine-associated hypersensitivity.疫苗相关过敏反应。
J Allergy Clin Immunol. 2018 Feb;141(2):463-472. doi: 10.1016/j.jaci.2017.12.971.
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Vaccination-related adverse events.疫苗接种相关不良事件。
Pediatr Emerg Care. 2006 Jul;22(7):514-9; quiz 520-2. doi: 10.1097/01.pec.0000227874.44878.40.
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Breath-holding spells in childhood.儿童屏气发作
Am J Dis Child. 1992 Jan;146(1):125-31. doi: 10.1001/archpedi.1992.02160130127035.

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