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贝那利珠单抗治疗与慢性嗜酸性粒细胞性肺炎三维支气管树变化

Benralizumab treatment and 3-dimensional bronchial tree changes in chronic eosinophilic pneumonia.

作者信息

Kai Yoshiro, Hishida Yuichi

机构信息

Department of Respiratory Medicine, Minami-Nara General Medical Center, Nara, Japan.

Department of Respiratory Medicine, Nara Medical University, Nara, Japan.

出版信息

J Allergy Clin Immunol Glob. 2025 Apr 25;4(3):100490. doi: 10.1016/j.jacig.2025.100490. eCollection 2025 Aug.

DOI:10.1016/j.jacig.2025.100490
PMID:40476092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12139403/
Abstract

Patients with chronic eosinophilic pneumonia often experience recurring disease and prolonged corticosteroid use with adverse effects. Benralizumab enabled corticosteroid discontinuation and successfully treated chronic eosinophilic pneumonia in our study, confirmed through remission induction therapy and 3-dimensional bronchial tree visualization.

摘要

慢性嗜酸性粒细胞性肺炎患者常经历疾病复发以及长期使用皮质类固醇带来的不良反应。在我们的研究中，贝那利珠单抗能够停用皮质类固醇，并成功治疗慢性嗜酸性粒细胞性肺炎，这通过诱导缓解疗法和三维支气管树可视化得到证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab90/12139403/4e4488978f04/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab90/12139403/5be1a0be6424/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab90/12139403/4e4488978f04/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab90/12139403/5be1a0be6424/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab90/12139403/4e4488978f04/gr2.jpg

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Benralizumab treatment and 3-dimensional bronchial tree changes in chronic eosinophilic pneumonia.贝那利珠单抗治疗与慢性嗜酸性粒细胞性肺炎三维支气管树变化
J Allergy Clin Immunol Glob. 2025 Apr 25;4(3):100490. doi: 10.1016/j.jacig.2025.100490. eCollection 2025 Aug.
2
Successful discontinuation of corticosteroids through remission induction therapy with benralizumab for chronic eosinophilic pneumonia.通过使用贝那利珠单抗进行缓解诱导治疗成功停用皮质类固醇治疗慢性嗜酸性粒细胞性肺炎。
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本文引用的文献

1
Successful discontinuation of corticosteroids through remission induction therapy with benralizumab for chronic eosinophilic pneumonia.通过使用贝那利珠单抗进行缓解诱导治疗成功停用皮质类固醇治疗慢性嗜酸性粒细胞性肺炎。
Respirol Case Rep. 2024 Jan 17;12(1):e01279. doi: 10.1002/rcr2.1279. eCollection 2024 Jan.
2
Case Report: Eosinophilic Bronchiolitis With Eosinophil ETosis in Mucus Plugs Successfully Treated With Benralizumab.病例报告：伴有黏液栓中嗜酸性粒细胞胞吐作用的嗜酸性细支气管炎经贝那利珠单抗成功治疗
Front Pharmacol. 2022 Jan 13;12:826790. doi: 10.3389/fphar.2021.826790. eCollection 2021.
3
Clinical characteristics of patients with chronic eosinophilic pneumonia in a Chinese tertiary-care hospital: A 6-year retrospective study.
中国一家三甲医院慢性嗜酸性粒细胞性肺炎患者的临床特征：一项 6 年回顾性研究。
Clin Respir J. 2022 Jan;16(1):35-42. doi: 10.1111/crj.13448. Epub 2021 Oct 5.
4
Possible Mechanisms of Eosinophil Accumulation in Eosinophilic Pneumonia.嗜酸性粒细胞性肺炎中嗜酸性粒细胞聚集的可能机制。
Biomolecules. 2020 Apr 21;10(4):638. doi: 10.3390/biom10040638.
5
The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: Asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis.IL-5 及其拮抗剂在嗜酸性粒细胞疾病中的作用：哮喘、嗜酸性肉芽肿伴多血管炎和嗜酸性慢性鼻-鼻窦炎。
Allergol Int. 2020 Apr;69(2):178-186. doi: 10.1016/j.alit.2020.02.002. Epub 2020 Mar 2.
6
Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction.哮喘黏液的尸检和影像学研究。关于疾病机制和黏液在气流阻塞中的作用的经验教训。
Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S184-S191. doi: 10.1513/AnnalsATS.201807-485AW.
7
Persistent impairment on spirometry in chronic eosinophilic pneumonia: A longitudinal observation study (Shizuoka-CEP study).慢性嗜酸性粒细胞性肺炎患者肺功能检查的持续损害：一项纵向观察研究（静冈慢性嗜酸性粒细胞性肺炎研究）
Ann Allergy Asthma Immunol. 2017 Nov;119(5):422-428.e2. doi: 10.1016/j.anai.2017.08.009. Epub 2017 Sep 21.
8
Measurement of FEF25-75% and FEF75% does not contribute to clinical decision making.用力呼出量 25%-75%（FEF25-75%）和 75%用力呼出量（FEF75%）的测量对临床决策无帮助。
Eur Respir J. 2014 Apr;43(4):1051-8. doi: 10.1183/09031936.00128113. Epub 2013 Sep 26.
9
Idiopathic chronic eosinophilic pneumonia and asthma: how do they influence each other?特发性慢性嗜酸性粒细胞性肺炎与哮喘：它们如何相互影响？
Eur Respir J. 2003 Jul;22(1):8-13. doi: 10.1183/09031936.03.00085603.