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Malignant ascites enhance γδ T cell cytotoxicity toward ovarian cancer chemokine-mediated recruitment.

作者信息

Yang Zhanqun, Liu Ying, Zheng Mengzhu, Li Hui, Cui Ruoyao, Wang Pan, He Tianhui, Guo Hongyan, Zhou Yinglin, Lin Jian, Chen Long

机构信息

Department of Pharmacy, Peking University Third Hospital Cancer Center, Peking University Third Hospital, Beijing 100191, China.

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

出版信息

Cancer Biol Med. 2025 Jun 6;22(6):639-43. doi: 10.20892/j.issn.2095-3941.2025.0072.

DOI:10.20892/j.issn.2095-3941.2025.0072
PMID:40476592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12240187/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2313/12240187/a733b8db3218/cbm-22-06-639-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2313/12240187/a733b8db3218/cbm-22-06-639-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2313/12240187/a733b8db3218/cbm-22-06-639-g001a.jpg

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本文引用的文献

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How chemokines organize the tumour microenvironment.趋化因子如何组织肿瘤微环境。
Nat Rev Cancer. 2024 Jan;24(1):28-50. doi: 10.1038/s41568-023-00635-w. Epub 2023 Dec 8.
2
γδ T cells: origin and fate, subsets, diseases and immunotherapy.γδ T 细胞：起源与命运、亚群、疾病与免疫治疗。
Signal Transduct Target Ther. 2023 Nov 22;8(1):434. doi: 10.1038/s41392-023-01653-8.
3
Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells.磷酸抗原将结合素 3A1 和 2A1 黏附，从而激活 Vγ9Vδ2 T 细胞。
Nature. 2023 Sep;621(7980):840-848. doi: 10.1038/s41586-023-06525-3. Epub 2023 Sep 6.
4
Ascites-induced compression alters the peritoneal microenvironment and promotes metastatic success in ovarian cancer.腹水诱导的压迫改变了腹膜微环境，促进了卵巢癌的转移成功。
Sci Rep. 2020 Jul 17;10(1):11913. doi: 10.1038/s41598-020-68639-2.
5
The untapped potential of ascites in ovarian cancer research and treatment.腹水在卵巢癌研究和治疗中的未开发潜力。
Br J Cancer. 2020 Jul;123(1):9-16. doi: 10.1038/s41416-020-0875-x. Epub 2020 May 8.
6
Development and validation of an immune gene-set based Prognostic signature in ovarian cancer.基于免疫基因集的卵巢癌预后标志物的建立和验证。
EBioMedicine. 2019 Feb;40:318-326. doi: 10.1016/j.ebiom.2018.12.054. Epub 2018 Dec 27.
7
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy.癌症微环境中的趋化因子及其在癌症免疫治疗中的相关性。
Nat Rev Immunol. 2017 Sep;17(9):559-572. doi: 10.1038/nri.2017.49. Epub 2017 May 30.
8
Proteome-metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication.卵巢癌腹水的蛋白质组-代谢组分析揭示了参与细胞间通讯的新成分。
Mol Cell Proteomics. 2014 Dec;13(12):3558-71. doi: 10.1074/mcp.M114.041194. Epub 2014 Sep 30.
9
Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research.应对卵巢癌腹水挑战：治疗和研究的新途径。
Nat Rev Cancer. 2013 Apr;13(4):273-82. doi: 10.1038/nrc3432. Epub 2013 Feb 21.
10
Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.强效变构CXCR1/CXCR2拮抗剂Sch527123的药理学特性
J Pharmacol Exp Ther. 2007 Aug;322(2):477-85. doi: 10.1124/jpet.106.118927. Epub 2007 May 11.