成功研发新冠疫苗过程中的当前进展与挑战
Current progress and challenges in the design and development of a successful COVID-19 vaccine.
作者信息
Li Tingting, Zhang Tianying, Gu Ying, Li Shaowei, Xia Ningshao
机构信息
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361102, China.
National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen University, Xiamen 361102, China.
出版信息
Fundam Res. 2021 Mar;1(2):139-150. doi: 10.1016/j.fmre.2021.01.011. Epub 2021 Jan 26.
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a worldwide concern, with little to no sign of a decreasing trend. There is a general consensus that normal life will be hampered until a safe and effective vaccine strategy is available and globally administered. Numerous countries have accelerated the clinical trials process for the development of a successful COVID-19 treatment, with over 200 candidates presently available for testing against SARS-CoV-2. Here, we provide an overview of the COVID-19 vaccine candidates currently in development, discuss the scientific and practical challenges associated with COVID-19 vaccine design, and share the potential strategies that could be exploited for vaccine design success.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）大流行仍是全球关注的问题，几乎没有下降趋势的迹象。人们普遍认为，在有安全有效的疫苗策略并在全球范围内实施之前，正常生活将受到阻碍。许多国家加快了COVID-19成功治疗方法的临床试验进程，目前有200多种候选药物可用于针对SARS-CoV-2的测试。在此，我们概述了目前正在研发的COVID-19候选疫苗，讨论了与COVID-19疫苗设计相关的科学和实际挑战，并分享了可能用于疫苗设计成功的潜在策略。
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