Tuta-Quintero Eduardo, Mora-Karam Claudia, Pimentel Juan
Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Sabana, Chía, Colombia.
Departamento de Medicina Familiar y Salud Pública, Universidad de La Sabana, Chía, Colombia.
Rev Colomb Reumatol. 2022 Jun;29:S7-S16. doi: 10.1016/j.rcreu.2022.03.008. Epub 2022 May 3.
Fibromyalgia is a syndrome characterized by chronic generalized pain, joint stiffness, sleep disorders, fatigue, anxiety and depressive episodes, whose clinical manifestations begin after a physical or emotional trauma. However, few publications describe the clinical impact of COVID-19 on fibromyalgia symptoms.
To map the available medical evidence on the impact of COVID-19 and PCS in patients with and without a diagnosis of fibromyalgia prior to infection.
Exploratory systematic review in PubMed and Scopus, considering articles in English and Spanish, with data on fibromyalgia in the population surviving SARS-CoV-2 infection. The clinical trial records of the World Health Organization databases were reviewed.
Twelve published articles were included: retrospective studies (n = 4), cross-sectional (n = 2), cases and controls (n = 2), qualitative studies (n = 2), a prospective cohort (n = 1) and a longitudinal section study (n = 1). The total study population of the included publications was 3,060 patients. In addition, one randomized controlled clinical trial and two observational cross-sectional and case-control studies were included. The total sum of the study population was 173 participants.
Survivors of COVID-19 with or without a previous diagnosis of fibromyalgia may present an increase in chronic pain, insomnia, joint stiffness, and deterioration in quality of life. The population with a history of fibromyalgia may be more affected by psychological stress, tissue damage to neuromuscular structures, and inflammation due to SARS-CoV-2 infection.
纤维肌痛是一种以慢性全身性疼痛、关节僵硬、睡眠障碍、疲劳、焦虑和抑郁发作为特征的综合征，其临床表现始于身体或情感创伤之后。然而，很少有出版物描述新冠病毒病（COVID-19）对纤维肌痛症状的临床影响。
梳理关于COVID-19和感染前有无纤维肌痛诊断的患者中新型冠状病毒感染后状况（PCS）影响的现有医学证据。
在PubMed和Scopus数据库中进行探索性系统综述，纳入英文和西班牙文文章，内容涉及感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的幸存者中的纤维肌痛数据。查阅了世界卫生组织数据库的临床试验记录。
纳入12篇已发表文章：回顾性研究（n = 4）、横断面研究（n = 2）、病例对照研究（n = 2）、定性研究（n = 2）、前瞻性队列研究（n = 1）和纵向研究（n = 1）。纳入出版物的研究总人群为3060例患者。此外，纳入了1项随机对照临床试验以及2项观察性横断面和病例对照研究。研究总人群共计173名参与者。
既往有无纤维肌痛诊断的COVID-19幸存者可能出现慢性疼痛加剧、失眠、关节僵硬以及生活质量下降。有纤维肌痛病史的人群可能更容易受到心理压力、神经肌肉结构组织损伤以及SARS-CoV-2感染所致炎症的影响。
