Sánchez-Romero Javier, Rodríguez-Contreras María, Rolle Valeria, Liandro Romina Sol, Pertegal-Ruiz Miriam, Muñoz-Contreras María, Blanco-Carnero José Eliseo, De Paco Matallana Catalina
Department of Obstetrics and Gynecology. 'Virgen de La Arrixaca, University Hospital, 30120, Murcia, Spain.
Department of Obstetrics, Gynecology, Surgery and Pediatrics, University of Murcia, 30120, Murcia, Spain.
Arch Gynecol Obstet. 2025 Jun 6. doi: 10.1007/s00404-025-08068-6.
This study aims to compare maternal and neonatal outcomes in singleton and twin pregnancies complicated by preeclampsia, emphasizing differences between preterm and term deliveries.
This is a retrospective study conducted at "Virgen de la Arrixaca" University Hospital (Murcia, Spain), from 2009 to 2020. Maternal demographic data and maternal and neonatal outcomes were collected from hospital records. Pregnancies were stratified by delivery before and after 37 weeks of gestation.
The study included 161 singleton pregnancies and 77 twin pregnancies, all complicated by preeclampsia. Preterm delivery rates (< 37 weeks) were significantly higher in twin compared to singletons (79.2% vs. 48.4%). The mean maternal hospital stay was longer in twins (9.0 days) than for singletons (7.6 days). Maternal complications occurred in 13.7% of singleton pregnancies and 28.6% of twin pregnancies (p = 0.006), with maternal hemorrhage more frequent in twins (22.1% vs. 9.3%; p = 0.007). Maternal complications were more common in twin pregnancies (OR = 3.13; 95%CI 1.38-7.10). Cesarean delivery (OR = 2.00; 95%CI 0.85-4.66) and BMI (OR = 0.96; 95%CI 0.90-1.03) were not associated with the maternal composite outcome. Neonatal complications occurred in 29.2% of singleton pregnancies and 30.0% of first twin and 27.3% of second twin (p = 0.890 and 0.790 respectively). Factors associated with neonatal complications included birthweight (OR 0.99; 95%CI 0.99-0.99) and delivery between 34 and 37 weeks of gestation (OR = 0.08; 95%CI 0.01-0.59) and delivery after 37 weeks of gestation (OR = 0.04; 95%CI 0.01-0.46).
Maternal complications were more frequent in twin pregnancies complicated by preeclampsia, while neoantal complications were more likely to occur in cases of preterm preeclampsia.
本研究旨在比较单胎和双胎妊娠并发子痫前期的母婴结局，重点关注早产和足月分娩之间的差异。
这是一项在西班牙穆尔西亚的“Virgen de la Arrixaca”大学医院进行的回顾性研究，研究时间为2009年至2020年。从医院记录中收集产妇的人口统计学数据以及母婴结局。妊娠按妊娠37周前后的分娩情况进行分层。
该研究纳入了161例单胎妊娠和77例双胎妊娠，所有病例均并发子痫前期。双胎妊娠的早产率（<37周）显著高于单胎妊娠（79.2%对48.4%）。双胎产妇的平均住院时间（9.0天）长于单胎产妇（7.6天）。13.7%的单胎妊娠和28.6%的双胎妊娠发生了母体并发症（p = 0.006），双胎妊娠中母体出血更为常见（22.1%对9.3%；p = 0.007）。母体并发症在双胎妊娠中更为常见（OR = 3.13；95%CI 1.38 - 7.10）。剖宫产（OR = 2.00；95%CI 0.85 - 4.66）和体重指数（OR = 0.96；95%CI 0.90 - 1.03）与母体综合结局无关。29.2%的单胎妊娠、30.0%的第一胎双胎和27.3%的第二胎双胎出现了新生儿并发症（分别为p = 0.890和0.790）。与新生儿并发症相关的因素包括出生体重（OR 0.99；95%CI 0.99 - 0.99）以及妊娠34至37周之间的分娩（OR = 0.08；95%CI 0.01 - 0.59）和妊娠37周后的分娩（OR = 0.04；95%CI 0.01 - 0.46）。
并发子痫前期的双胎妊娠中母体并发症更为常见，而早产子痫前期病例中更易发生新生儿并发症。
