Ding Wenyan, Chen Xiaofang, Tian Yuan, Wang Yanyue, Zhang Chi
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hengyang Medical School, University of South China, Hengyang, Hunan, People's Republic of China.
Research Laboratory of Translational Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, People's Republic of China.
J Physiol. 2025 Jun 6. doi: 10.1113/JP288459.
Cardiovascular disease is the predominant cause of mortality globally, with both morbidity and mortality rates escalating annually. Non-coding RNAs are essential in the regulation of cardiovascular disease. Exosomes are lipid bilayer vesicles that are released by many types of cells. They carry biomolecules such as proteins and nucleic acids (e.g. microRNAs, circular RNAs and long non-coding RNAs). The physiological condition of the mother cell significantly affects their composition and biological activity. In cardiovascular disorders, macrophages generate exosomes that facilitate intercellular communication, potentially resulting in new therapeutic strategies for these conditions. In this article, we examine the impact of exosomal non-coding RNAs derived from macrophages on the functionality and condition of immune cells, vascular smooth muscle cells, endothelial cells, cardiomyocytes and cardiac fibroblasts. They facilitate intercellular communication via several mechanisms. Non-coding RNAs generated from macrophage exosomes significantly influence cellular functional states and might offer new approaches for preventing and treating cardiovascular disorders. Owing to insufficient clinical evidence, additional extensive investigations are required to assess the therapeutic potential of these non-coding RNAs in cardiovascular disorders.
心血管疾病是全球主要的死亡原因，其发病率和死亡率均逐年上升。非编码RNA在心血管疾病的调控中至关重要。外泌体是由多种类型的细胞释放的脂质双分子层囊泡。它们携带蛋白质和核酸等生物分子（如微小RNA、环状RNA和长链非编码RNA）。母细胞的生理状态会显著影响它们的组成和生物活性。在心血管疾病中，巨噬细胞产生的外泌体促进细胞间通讯，这可能为这些疾病带来新的治疗策略。在本文中，我们研究了巨噬细胞来源的外泌体非编码RNA对免疫细胞、血管平滑肌细胞、内皮细胞、心肌细胞和心脏成纤维细胞的功能和状态的影响。它们通过多种机制促进细胞间通讯。巨噬细胞外泌体产生的非编码RNA显著影响细胞功能状态，并可能为预防和治疗心血管疾病提供新方法。由于临床证据不足，需要进行更多广泛的研究来评估这些非编码RNA在心血管疾病中的治疗潜力。
