Griffith Julianne M, Wears Anna, McDonald Nastasia O, Silk Jennifer S, Price Rebecca B, Woody Mary L
University of Pittsburgh School of Medicine, Department of Psychiatry, USA.
University of Pittsburgh School of Medicine, Department of Psychiatry, USA; University of Pittsburgh, Department of Social Work, USA; University of Pittsburgh, Department of Public Health, USA.
Dev Cogn Neurosci. 2025 Jun 3;74:101579. doi: 10.1016/j.dcn.2025.101579.
Risk for depression rises during adolescence, particularly among children of depressed mothers. Altered neurophysiological reward processing, measured using event-related potentials (ERPs), is related to depression vulnerability. However, it is unclear whether disruptions in youth reward responsiveness are driven by parental reward dysfunction (e.g., anhedonia) versus parent-child relationship factors (e.g., closeness). This work examined concurrent and prospective associations between youth neurophysiological reward responsiveness and parental anhedonia, parent-adolescent discord, and parent-adolescent closeness. Participants included 93 youth assigned female at birth (ages 13-15) and their mothers (n = 62 with a depression history). Youth reward responsiveness was assessed at baseline and one-year follow-up using the reward positivity (RewP) ERP component. Parental anhedonia, parent-adolescent discord, and parent-adolescent closeness were measured at each timepoint using questionnaires. Regression analyses demonstrated positive concurrent associations between parent-adolescent closeness and youth RewP at both timepoints. RewP was not significantly related to parental anhedonia or parent-adolescent discord, and no prospective cross-lagged effects were observed. Among adolescents at varying depression risk, youth with greater closeness with their mothers consistently demonstrated enhanced reward responsiveness, even after accounting for adolescent depressive symptoms and maternal depression history. Findings suggest that positive, but not negative, aspects of parent-child relationships are related to adolescent responsiveness to reward.
抑郁症风险在青春期会上升，在母亲患有抑郁症的孩子中尤为明显。使用事件相关电位（ERP）测量的神经生理奖励处理改变与抑郁症易感性有关。然而，尚不清楚青少年奖励反应的破坏是由父母奖励功能障碍（如快感缺失）还是亲子关系因素（如亲密程度）驱动的。这项研究考察了青少年神经生理奖励反应与父母快感缺失、亲子不和以及亲子亲密程度之间的同时期和前瞻性关联。参与者包括93名出生时被指定为女性的青少年（年龄在13至15岁之间）及其母亲（n = 62，有抑郁症病史）。在基线和一年随访时，使用奖励正性（RewP）ERP成分评估青少年的奖励反应。在每个时间点使用问卷测量父母快感缺失、亲子不和以及亲子亲密程度。回归分析表明，在两个时间点，亲子亲密程度与青少年RewP之间均存在正的同时期关联。RewP与父母快感缺失或亲子不和无显著相关性，也未观察到前瞻性交叉滞后效应。在不同抑郁风险的青少年中，与母亲关系更亲密的青少年即使在考虑了青少年抑郁症状和母亲抑郁症病史后，也始终表现出增强的奖励反应。研究结果表明，亲子关系的积极而非消极方面与青少年对奖励的反应有关。
