Dude Annie, Wascher Jocelyn
Division of Maternal - Fetal Medicine, Department of Obstetrics & Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (A.D.).
Division of Family Planning, Department of Obstetrics & Gynecology, University of Chicago, Chicago, IL, USA (J.W.).
Am J Obstet Gynecol MFM. 2025 Aug;7(8):101713. doi: 10.1016/j.ajogmf.2025.101713. Epub 2025 Jun 4.
Prior studies indicate that unintended and unwanted pregnancies can be associated with poor obstetric outcomes.
This study examined whether an unintended or unwanted pregnancy was associated with a preterm delivery and with low birth weight.
We conducted a secondary analysis of the 2017 to 2019 cycle of the National Survey of Family Growth, a nationally-representative population- based survey of reproductive-aged people identifying as female in the United States. The sample consisted of respondents who had at least one prior live birth. Respondents were asked whether their most recent pregnancy was wanted (either at that time or prior to that time), unintended (wanted, but too soon, or unwanted at any time), or unwanted (did not want to be pregnant at any time). The primary outcomes were preterm delivery, defined as a live birth prior to 37 weeks' gestation, and low birth weight, defined as a birthweight less than 2500 grams. We also examined early preterm delivery (defined as a live birth prior to 34 weeks' gestation) as a secondary outcome, as well as restricting the sample to term deliveries only to examine low birth weight. We used chi square and Wilcoxon rank sum analysis for bivariable comparisons and logistic regression for multivariable models.
Our sample consisted of 3299 unique deliveries, 35.4% of which resulted from unintended pregnancies and 16.9% of which resulted from unwanted pregnancies. Overall, 12.7% of respondents had any preterm delivery, including 11.3% of those with intended pregnancies, 15.4% of those with unintended pregnancies (p=.02), 11.9% of those with wanted pregnancies and 16.9% of those with unwanted pregnancies (p=.01). Of the overall sample, 3.7% had a preterm delivery prior to 34 weeks gestation, including 3.0% of those with an intended pregnancy, 4.9% of those with an unintended pregnancy (p=.10), 3.1% of those with wanted pregnancies, and 6.3% of those with unwanted pregnancies (p=.01). Unwanted pregnancies remained associated with preterm delivery and early preterm delivery after adjusting for confounders (adjusted odds ratio 1.42, 95% confidence interval 1.02 to 1.98 for any preterm delivery, adjusted odds ratio 1.84, 95% confidence interval 1.10 to 3.08 for early preterm delivery). In our sample, 8.0% of respondents had a low birth weight neonate, including 6.6% of those with an intended pregnancy, 10.5% of those with an unintended pregnancy (p=.02), 7.4% of those with wanted and 10.5% of those with unwanted pregnancies (p=.10). These results were insignificant among those with term deliveries and after adjusting for confounders.
Unwanted pregnancies are associated with an increased risk of preterm delivery, but not low birth weight.
先前的研究表明,意外怀孕和意外妊娠可能与不良产科结局相关。
本研究调查意外或意外妊娠是否与早产及低出生体重有关。
我们对2017 - 2019年全国家庭生育调查周期进行了二次分析,这是一项基于全国代表性人群的针对美国自我认定为女性的育龄人群的调查。样本包括至少有一次既往活产的受访者。受访者被问及他们最近一次怀孕是想要的(当时或之前想要)、意外的(想要,但时机过早,或在任何时候都不想要)还是不想要的(在任何时候都不想怀孕)。主要结局是早产,定义为妊娠37周前的活产,以及低出生体重,定义为出生体重低于2500克。我们还将早期早产(定义为妊娠34周前的活产)作为次要结局进行研究,并将样本限制为仅足月分娩以研究低出生体重。我们使用卡方检验和Wilcoxon秩和分析进行双变量比较,并使用逻辑回归进行多变量模型分析。
我们的样本包括3299例独特分娩,其中35.4%为意外怀孕导致,16.9%为意外妊娠导致。总体而言,12.7%的受访者有任何早产情况,包括11.3%的有意妊娠者、15.4%的意外妊娠者(p = 0.02)、11.9%的想要妊娠者和16.9%的意外妊娠者(p = 0.01)。在整个样本中,3.7%的人在妊娠34周前早产,包括3.0%的有意妊娠者、4.9%的意外妊娠者(p = 0.10)、3.1%的想要妊娠者和6.3%的意外妊娠者(p = 0.01)。在调整混杂因素后,意外妊娠仍然与早产和早期早产相关(任何早产的调整优势比为1.42,95%置信区间为1.02至1.98;早期早产的调整优势比为1.84,95%置信区间为1.10至3.08)。在我们的样本中,8.0%的受访者有低出生体重新生儿,包括6.6%的有意妊娠者、10.5%的意外妊娠者(p = 0.02)、7.4%的想要妊娠者和10.5%的意外妊娠者(p = 0.10)。在足月分娩者中以及调整混杂因素后,这些结果无统计学意义。
意外妊娠与早产风险增加相关,但与低出生体重无关。