Nakaguchi Kazeto, Ohtani Shunsuke, Kato Kenichi, Ogoshi Tomoki
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.
Chemistry. 2025 Jul 8;31(38):e202500755. doi: 10.1002/chem.202500755. Epub 2025 Jun 17.
Numerous macrocyclic arenes have been synthesized from various types of aromatic monomers. However, the rotation of monomer units often reduces the internal cavity volume. To address this issue, seven-membered-ring-fused monomers were employed for the synthesis of macrocyclic arenes. The fusion of aromatic units via seven-membered rings introduces a bent geometry into the macrocyclic framework, which reduces conformational flexibility and helps preserve a stable and expanded internal cavity in both solution and solid states.
许多大环芳烃已由各种类型的芳香族单体合成。然而，单体单元的旋转通常会减小内腔体积。为了解决这个问题，七元环稠合单体被用于合成大环芳烃。通过七元环对芳香单元的稠合将弯曲几何形状引入大环骨架，这降低了构象灵活性，并有助于在溶液和固态中保持稳定且扩大的内腔。
