天然产物作为抗顶复门寄生虫的下一代药物来源的综述。
A review of natural products as a source of next-generation drugs against apicomplexan parasites.
作者信息
Mao Emma Y, Page Stephen W, Sleebs Brad E, Gancheva Maria R, Wilson Danny W
机构信息
Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.
ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (CEAStAR), St Lucia, Queensland, Australia.
出版信息
NPJ Antimicrob Resist. 2025 Jun 6;3(1):51. doi: 10.1038/s44259-025-00119-x.
Despite the substantial global health and economic burden of apicomplexan parasites in humans and livestock, treatment options remain limited. Natural products have long played an important role in combating these diseases, offering diverse chemical structures and bioactive compounds. This review summarises past and present natural-product-based therapies for six economically significant apicomplexans and explores the potential of revisiting natural products as a source of next-generation treatments.
尽管顶复门寄生虫给人类和牲畜带来了巨大的全球健康和经济负担，但治疗选择仍然有限。长期以来，天然产物在对抗这些疾病方面发挥了重要作用，提供了多样的化学结构和生物活性化合物。本综述总结了过去和现在针对六种具有经济重要性的顶复门寄生虫的基于天然产物的疗法，并探讨了重新审视天然产物作为下一代治疗来源的潜力。
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