Frederiksen Rikki Franklin, Slettemeås Jannice Schau, Granstad Silje, Lagesen Karin, Pikkemaat Mariel G, Urdahl Anne Margrete, Simm Roger
Department of Animal Health, Welfare and Food Safety, Norwegian Veterinary Institute, Ås, Norway.
Wageningen Food Safety Research, Wageningen University and Research, Wageningen, Netherlands.
Front Microbiol. 2024 Jan 29;15:1347490. doi: 10.3389/fmicb.2024.1347490. eCollection 2024.
Antimicrobial resistance is a major threat to human health and must be approached from a One Health perspective. Use of antimicrobials in animal husbandry can lead to dissemination and persistence of resistance in human pathogens. Polyether ionophores (PIs) have antimicrobial activities and are among the most extensively used feed additives for major production animals. Recent discoveries of genetically encoded PI resistance mechanisms and co-localization of resistance mechanisms against PIs and antimicrobials used in human medicine on transferrable plasmids, have raised concerns that use of PIs as feed additives bear potential risks for human health. This review summarizes the current knowledge on PI resistance and discusses the potential consequences of PI-usage as feed additives in a One Health perspective.
抗菌素耐药性是对人类健康的重大威胁，必须从“同一健康”的角度来应对。畜牧业中使用抗菌素会导致人类病原体中的耐药性传播和持续存在。聚醚离子载体（PIs）具有抗菌活性，是主要养殖动物使用最广泛的饲料添加剂之一。最近关于基因编码的PI耐药机制的发现，以及针对PIs和人类医学中使用的抗菌素的耐药机制在可转移质粒上的共定位，引发了人们对将PIs用作饲料添加剂对人类健康存在潜在风险的担忧。本综述总结了目前关于PI耐药性的知识，并从“同一健康”的角度讨论了将PI用作饲料添加剂的潜在后果。
