轴性脊柱关节炎和银屑病关节炎患者心理特征及生活质量决定因素的性别差异：一项横断面研究
Gender differences in psychological features and determinates of quality of life in axial spondyloarthritis and psoriatic arthritis: a cross-sectional study.
作者信息
Ristic Branko, Carletto Antonio, Fracassi Elena, Cristofalo Doriana, Rossini Maurizio, Maggioni Lucia, Scagliosi Giorgia, Veliaj Olta, Bonetto Chiara, Tosato Sarah
机构信息
Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, P.Le Scuro 10, Verona, VR, 37134, Italy.
Department of Medicine, Rheumatology Unit, University of Verona, Verona, Italy.
出版信息
BMC Psychol. 2025 Jun 6;13(1):619. doi: 10.1186/s40359-025-02889-5.
BACKGROUND
Investigating gender-specific differences in rheumatology is crucial for improving personalized treatment. The present study aimed to explore gender differences in psychological characteristics and features associated with impaired physical and mental quality of life in male and female patients affected by axial spondyloarthritis or psoriatic arthritis.
METHODS
The present study is cross-sectional. Quality of life was evaluated using a Medical Outcome Study 36-item Short Form health survey (SF-36), and physical and mental component scores were presented. Data about disease activity, anxiety and depression, fatigue, perceived stress, and coping strategies were collected. The patients were stratified by gender, and clinical and psychological data were compared.
RESULTS
A total of 119 patients with axial spondyloarthritis [age 49.0 (SD 11.7); 45.4% F] and 198 patients with psoriatic arthritis [age 56.9 (SD 11.6); 62.6% F] were included. Female patients with axial spondyloarthritis and psoriatic arthritis had worse scores on fatigue, pain, perceived stress, physical quality of life, dysfunctional coping strategies, mental quality of life (only in axial spondyloarthritis), and anxiety (only in psoriatic arthritis) than men. In multivariable analysis, physical quality of life is mainly explained by fatigue and pain, and mental quality of life by fatigue, anxiety and stress in women with axial spondyloarthritis and psoriatic arthritis. Fatigue, pain and anxiety were significant variables across the models with male patients.
CONCLUSIONS
The study indicates that female patients with axial spondyloarthritis and psoriatic arthritis experience worse scores in psychological variables compared to men. Additionally, women's quality of life is significantly lower when compared to men's one, primarily due to factors such as fatigue, stress, pain, and anxiety. To enhance patient well-being, therapeutic strategies should be tailored to address the unique clinical and psychological needs that arise from gender differences.
背景
研究风湿病中的性别差异对于改善个性化治疗至关重要。本研究旨在探讨患有轴性脊柱关节炎或银屑病关节炎的男性和女性患者在心理特征以及与身心健康生活质量受损相关的特征方面的性别差异。
方法
本研究为横断面研究。使用医学结局研究36项简表健康调查（SF - 36）评估生活质量，并给出身体和心理成分得分。收集有关疾病活动、焦虑和抑郁、疲劳、感知压力及应对策略的数据。患者按性别分层，并比较临床和心理数据。
结果
共纳入119例轴性脊柱关节炎患者[年龄49.0（标准差11.7）；女性占45.4%]和198例银屑病关节炎患者[年龄56.9（标准差11.6）；女性占62.6%]。患有轴性脊柱关节炎和银屑病关节炎的女性患者在疲劳、疼痛、感知压力、身体生活质量、功能失调的应对策略、心理生活质量（仅在轴性脊柱关节炎中）以及焦虑（仅在银屑病关节炎中）方面的得分比男性更差。在多变量分析中，对于患有轴性脊柱关节炎和银屑病关节炎的女性患者，身体生活质量主要由疲劳和疼痛解释，心理生活质量由疲劳、焦虑和压力解释。对于男性患者，疲劳、疼痛和焦虑是各模型中的显著变量。
结论
该研究表明，与男性相比，患有轴性脊柱关节炎和银屑病关节炎的女性患者在心理变量方面得分更差。此外，与男性相比，女性的生活质量显著更低，主要是由于疲劳、压力、疼痛和焦虑等因素。为提高患者的幸福感，治疗策略应针对性别差异所产生的独特临床和心理需求进行调整。
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